6SUH

Crystal structure of human transthyretin in complex with 3-O-methyltolcapone, a tolcapone analogue

Summary for 6SUH

Entry DOI	10.2210/pdb6suh/pdb
Descriptor	Transthyretin, 3-O-methyltolcapone (3 entities in total)
Functional Keywords	amyloidosis, tetramer, binding protein, transport protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	32384.50
Authors	Loconte, V.,Cianci, M.,Menozzi, I.,Sbravati, D.,Sansone, F.,Casnati, A.,Berni, R. (deposition date: 2019-09-14, release date: 2020-08-05, Last modification date: 2024-01-24)
Primary citation	Loconte, V.,Cianci, M.,Menozzi, I.,Sbravati, D.,Sansone, F.,Casnati, A.,Berni, R. Interactions of tolcapone analogues as stabilizers of the amyloidogenic protein transthyretin. Bioorg.Chem., 103:104144-104144, 2020 Cited by PubMed: 32791384 DOI: 10.1016/j.bioorg.2020.104144 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.26 Å)

Structure validation