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6SUH

Crystal structure of human transthyretin in complex with 3-O-methyltolcapone, a tolcapone analogue

Functional Information from GO Data
ChainGOidnamespacecontents
A0042572biological_processretinol metabolic process
A0070324molecular_functionthyroid hormone binding
A0070327biological_processthyroid hormone transport
B0042572biological_processretinol metabolic process
B0070324molecular_functionthyroid hormone binding
B0070327biological_processthyroid hormone transport
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue LVE A 201
ChainResidue
ALYS15
ATHR119
AVAL121
ALYS15
ALEU17
ALEU17
AALA108
AALA108
ASER117
ATHR118
ATHR119

site_idAC2
Number of Residues11
Detailsbinding site for residue LVE B 201
ChainResidue
BLYS15
BLYS15
BLEU17
BLEU17
BALA108
BALA108
BSER117
BTHR118
BTHR119
BTHR119
BVAL121

Functional Information from PROSITE/UniProt
site_idPS00768
Number of Residues16
DetailsTRANSTHYRETIN_1 Transthyretin signature 1. KVLDavrGsPAinVaV
ChainResidueDetails
ALYS15-VAL30

site_idPS00769
Number of Residues13
DetailsTRANSTHYRETIN_2 Transthyretin signature 2. YTIAalLSPYSYS
ChainResidueDetails
ATYR105-SER117

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11418763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ICT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"Sulfocysteine","evidences":[{"source":"PubMed","id":"17175208","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2H4E","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"4-carboxyglutamate; in a patient with Moyamoya disease","evidences":[{"source":"PubMed","id":"18221012","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P02767","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19167329","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

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