7QC5

Crystal structure of human wild type transthyretin in complex with (3,4-dihydroxy-5-nitrophenyl)-(3-fluoro-5-hydroxyphenyl)methanone compound

Summary for 7QC5

Entry DOI	10.2210/pdb7qc5/pdb
Descriptor	Transthyretin, (3-fluoranyl-5-oxidanyl-phenyl)-[3-nitro-4,5-bis(oxidanyl)phenyl]methanone (3 entities in total)
Functional Keywords	thyroxine (t4) binding site, stabilization compound, amyloid fibrils., transport protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	28141.13
Authors	Varejao, N.,Pinheiro, F.,Pallares, I.,Ventura, S.,Reverter, D. (deposition date: 2021-11-22, release date: 2022-11-30, Last modification date: 2024-01-31)
Primary citation	Pinheiro, F.,Pallares, I.,Peccati, F.,Sanchez-Morales, A.,Varejao, N.,Bezerra, F.,Ortega-Alarcon, D.,Gonzalez, D.,Osorio, M.,Navarro, S.,Velazquez-Campoy, A.,Almeida, M.R.,Reverter, D.,Busque, F.,Alibes, R.,Sodupe, M.,Ventura, S. Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation. J.Med.Chem., 65:14673-14691, 2022 Cited by PubMed: 36306808 DOI: 10.1021/acs.jmedchem.2c01195 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.2 Å)

Structure validation