4D7B
Structure of human transthyretin in complex with Tolcapone
Summary for 4D7B
| Entry DOI | 10.2210/pdb4d7b/pdb |
| Descriptor | TRANSTHYRETIN, Tolcapone (3 entities in total) |
| Functional Keywords | transport protein, amyloidogenesis |
| Biological source | HOMO SAPIENS (HUMAN) |
| Cellular location | Secreted: P02766 |
| Total number of polymer chains | 2 |
| Total formula weight | 28363.60 |
| Authors | Gallego, P.,Sant'anna, R.O.,Ventura, S.,Reverter, D. (deposition date: 2014-11-21, release date: 2016-01-20, Last modification date: 2016-03-02) |
| Primary citation | Reverter, D.,Gallego, P.,Santana, R.,Ventura, S. Repositioning Tolcapone as a Potent Inhibitor of Transthyretin Amyloidogenesis and its Associated Cellular Toxicity Nat.Commun., 7:10787-, 2016 Cited by PubMed: 26902880DOI: 10.1038/NCOMMS10787 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.15 Å) |
Structure validation
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