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PDB: 13 results

3W7F
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BU of 3w7f by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from staphylococcus aureus complexed with farnesyl thiopyrophosphate
Descriptor: Dehydrosqualene synthase, MAGNESIUM ION, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H, Oldfield, E.
Deposit date:2013-02-28
Release date:2013-04-10
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
Science, 319, 2008
2ZCQ
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BU of 2zcq by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-652
Descriptor: (1R)-4-(3-phenoxyphenyl)-1-phosphonobutane-1-sulfonic acid, Dehydrosqualene synthase, MAGNESIUM ION
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H, Oldfield, E.
Deposit date:2007-11-11
Release date:2008-03-11
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
Science, 319, 2008
2ZCS
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BU of 2zcs by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-700
Descriptor: Dehydrosqualene synthase, tripotassium (1R)-4-biphenyl-4-yl-1-phosphonatobutane-1-sulfonate
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H, Oldfield, E.
Deposit date:2007-11-11
Release date:2008-03-11
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
Science, 319, 2008
2ZCO
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BU of 2zco by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus
Descriptor: Dehydrosqualene synthase
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H, Oldfield, E.
Deposit date:2007-11-11
Release date:2008-03-11
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
Science, 319, 2008
2ZCR
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BU of 2zcr by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-698
Descriptor: Dehydrosqualene synthase, MAGNESIUM ION, tripotassium (1R)-4-(4'-butylbiphenyl-4-yl)-1-phosphonatobutane-1-sulfonate
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H, Oldfield, E.
Deposit date:2007-11-11
Release date:2008-03-11
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
Science, 319, 2008
3VJE
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Crystal structure of the Y248A mutant of C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus in complex with zaragozic acid A
Descriptor: Dehydrosqualene synthase, Zaragozic acid A
Authors:Liu, C.I, Jeng, W.Y, Chang, W.J, Wang, A.H.J.
Deposit date:2011-10-14
Release date:2012-04-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase
J.Biol.Chem., 287, 2012
3VJD
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BU of 3vjd by Molmil
Crystal structure of the Y248A mutant of C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus
Descriptor: Dehydrosqualene synthase, L(+)-TARTARIC ACID
Authors:Liu, C.I, Jeng, W.Y, Chang, W.J, Wang, A.H.J.
Deposit date:2011-10-14
Release date:2012-04-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase
J.Biol.Chem., 287, 2012
3ADZ
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BU of 3adz by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with intermediate PSPP
Descriptor: Dehydrosqualene synthase, MAGNESIUM ION, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H.J, Oldfield, E.
Deposit date:2010-01-31
Release date:2010-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Mechanism of action and inhibition of dehydrosqualene synthase.
Proc.Natl.Acad.Sci.USA, 107, 2010
3AE0
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BU of 3ae0 by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with geranylgeranyl thiopyrophosphate
Descriptor: Dehydrosqualene synthase, MAGNESIUM ION, phosphonooxy-[(10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]sulfanyl-phosphinic acid
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H.J, Oldfield, E.
Deposit date:2010-01-31
Release date:2010-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Mechanism of action and inhibition of dehydrosqualene synthase.
Proc.Natl.Acad.Sci.USA, 107, 2010
3ACW
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BU of 3acw by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with BPH-651
Descriptor: (3R)-3-biphenyl-4-yl-1-azabicyclo[2.2.2]octan-3-ol, Dehydrosqualene synthase
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H.J, Oldfield, E.
Deposit date:2010-01-13
Release date:2010-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Mechanism of action and inhibition of dehydrosqualene synthase
Proc.Natl.Acad.Sci.USA, 107, 2010
3ACX
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BU of 3acx by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with BPH-673
Descriptor: Dehydrosqualene synthase, N-(1-methylethyl)-3-[(3-prop-2-en-1-ylbiphenyl-4-yl)oxy]propan-1-amine
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H.J, Oldfield, E.
Deposit date:2010-01-13
Release date:2010-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Mechanism of action and inhibition of dehydrosqualene synthase
Proc.Natl.Acad.Sci.USA, 107, 2010
3ACY
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BU of 3acy by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with BPH-702
Descriptor: (1R)-4-[3-(2-benzylphenoxy)phenyl]-1-phosphonobutane-1-sulfonic acid, Dehydrosqualene synthase, MAGNESIUM ION
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H.J, Oldfield, E.
Deposit date:2010-01-13
Release date:2010-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Mechanism of action and inhibition of dehydrosqualene synthase
Proc.Natl.Acad.Sci.USA, 107, 2010
2ZY1
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BU of 2zy1 by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-830
Descriptor: Dehydrosqualene synthase, dipotassium (2-oxo-2-{[3-(3-phenoxyphenyl)propyl]amino}ethyl)phosphonate
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H.J, Oldfield, E.
Deposit date:2009-01-10
Release date:2009-09-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results.
J.Med.Chem., 52, 2009

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