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3MFI	DNA Polymerase Eta in Complex With a cis-syn Thymidine Dimer Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-D(*GP*TP*CP*CP*TP*CP*CP*CP*CP*TP*(DOC))-3', 5'-D(*TP*AP*AP*(TTD)P*GP*AP*GP*GP*GP*GP*AP*GP*GP*AP*C)-3', ... Authors: Silverstein, T.D, Johnson, R.E, Jain, R, Prakash, L, Prakash, S, Aggarwal, A.K. Deposit date: 2010-04-02 Release date: 2010-06-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Structural basis for the suppression of skin cancers by DNA polymerase eta. Nature, 465, 2010
3MFH	DNA Polymerase Eta in Complex With Undamaged DNA Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-D(*GP*TP*CP*CP*TP*CP*CP*CP*CP*TP*(DOC))-3', 5'-D(*TP*AP*AP*TP*TP*GP*AP*GP*GP*GP*GP*AP*GP*GP*AP*C)-3', ... Authors: Silverstein, T.D, Johnson, R.E, Jain, R, Prakash, L, Prakash, S, Aggarwal, A.K. Deposit date: 2010-04-02 Release date: 2010-06-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for the suppression of skin cancers by DNA polymerase eta. Nature, 465, 2010
8SKI	Crystal structure of human DNA polymerase eta incorporating 5F-dUTP across HX Descriptor: 2'-deoxy-5-fluorouridine 5'-(tetrahydrogen triphosphate), CALCIUM ION, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), ... Authors: Jung, H. Deposit date: 2023-04-19 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (2.163 Å) Cite: Crystal structure of human DNA polymerase eta incorporating 5F-dUTP across dA To Be Published
7L69	Crystal structure of human polymerase eta complexed with syn N7-benzylguanine Descriptor: DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(*CP*AP*TP*(7BG)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), DNA polymerase eta Authors: Jung, H, Lee, S. Deposit date: 2020-12-23 Release date: 2022-01-05 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Crystal structure of human polymerase eta complexed with syn N7-benzylguanine To Be Published
2I5O	Solution Structure of the Ubiquitin-Binding Zinc Finger (UBZ) Domain of the Human DNA Y-Polymerase Eta Descriptor: DNA polymerase eta, ZINC ION Authors: Zhou, P, Bomar, M.G. Deposit date: 2006-08-25 Release date: 2007-03-13 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Structure of the ubiquitin-binding zinc finger domain of human DNA Y-polymerase eta. Embo Rep., 8, 2007
3TQ1	Human DNA Polymerase eta in binary complex with DNA Descriptor: DNA (5'-D(*TP*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*TP*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta Authors: Ummat, A, Silverstein, T.D, Jain, R, Buku, A, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. Deposit date: 2011-09-08 Release date: 2012-02-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.556 Å) Cite: Human DNA Polymerase Eta Is Pre-Aligned for dNTP Binding and Catalysis. J.Mol.Biol., 415, 2012
6UI2	Structure of human DNA polymerase eta complexed with N7MG in the template base paired with incoming non-hydrolyzable CTP Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(FMG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... Authors: Koag, M.C, Lee, S. Deposit date: 2019-09-30 Release date: 2020-01-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Bypass of the Major Alkylative DNA Lesion by Human DNA Polymerase eta. Molecules, 24, 2019
6UQI	Crystal structure of Q38A human DNA polymerase eta bound with 8-oxoadenine (oxoA) and non-hydrolyzable dGTP analog (dGTP*) Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(A38)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... Authors: Jung, H, Lee, S. Deposit date: 2019-10-19 Release date: 2020-10-28 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of Q38A human DNA polymerase eta bound with 8-oxoadenine (oxoA) and non-hydrolyzable dGTP analog (dGTP*) To Be Published
6D0M	Polymerase Eta post-insertion binary complex with cytarabine (AraC) Descriptor: DNA (5'-D(*CP*AP*TP*GP*AP*CP*AP*GP*TP*GP*CP*T)-3'), DNA polymerase eta, DNA/RNA (5'-D(*AP*GP*CP*AP*CP*TP*GP*T)-R(P*(CAR))-3'), ... Authors: Rechkoblit, O, Aggarwal, A.K. Deposit date: 2018-04-10 Release date: 2018-09-05 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.832 Å) Cite: Structural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine. Sci Rep, 8, 2018
3JAA	HUMAN DNA POLYMERASE ETA in COMPLEX WITH NORMAL DNA AND INCO NUCLEOTIDE (NRM) Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*T*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3, DNA (5'-D(*TP*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... Authors: Lau, W.C.Y, Li, Y, Zhang, Q, Huen, M.S.Y. Deposit date: 2015-05-19 Release date: 2015-12-23 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (22 Å) Cite: Molecular architecture of the Ub-PCNA/Pol eta complex bound to DNA Sci Rep, 5, 2015
6D0Z	Polymerase Eta cytarabine (AraC) extension ternary complex Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*TP*TP*GP*CP*AP*GP*TP*GP*CP*T)-3'), DNA polymerase eta, ... Authors: Rechkoblit, O, Aggarwal, A.K. Deposit date: 2018-04-11 Release date: 2018-09-05 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine. Sci Rep, 8, 2018
3WUP	Crystal Structure of the Ubiquitin-Binding Zinc Finger (UBZ) Domain of the Human DNA Polymerase Eta Descriptor: CHLORIDE ION, DNA polymerase eta, GLYCEROL, ... Authors: Suzuki, N, Wakatsuki, S, Kawasaki, S. Deposit date: 2014-05-01 Release date: 2015-06-17 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (1.6 Å) Cite: A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1. Febs J., 283, 2016
3SI8	Human DNA polymerase eta - DNA ternary complex with the 5'T of a CPD in the active site (TT2) Descriptor: (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, ... Authors: Biertumpfel, C, Zhao, Y, Kondo, Y, Ramon-Maiques, S, Gregory, M, Lee, J.Y, Masutani, C, Lehmann, A.R, Hanaoka, F, Yang, W. Deposit date: 2011-06-17 Release date: 2011-08-03 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structure and mechanism of human DNA polymerase eta. Nature, 465, 2010
6V5K	Crystal structure of human DNA polymerase eta complexed with N7-nitrogen half-mustard guanine (NHMG) and dCTP* Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(*CP*AP*T*(QRV)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), ... Authors: Jung, H, Lee, S. Deposit date: 2019-12-04 Release date: 2020-12-09 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Crystal structure of human DNA polymerase eta complexed with N7-nitrogen half-mustard guanine (NHMG) and dCTP* To Be Published
6W5X	Crystal structure of human polymerase eta complexed with N7-benzylguanine and dCTP* Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(*CP*AP*TP*(DRG)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), ... Authors: Jung, H, Lee, S. Deposit date: 2020-03-14 Release date: 2021-03-17 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.59 Å) Cite: Crystal structure of human polymerase eta complexed with N7-benzylguanine and dCTP* To Be Published
6WK6	Crystal structure of human polymerase eta complexed with Xanthine containing DNA Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(*CP*AP*TP*(3ZO)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), ... Authors: Jung, H, Lee, S. Deposit date: 2020-04-15 Release date: 2021-01-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Structural insights into the bypass of the major deaminated purines by translesion synthesis DNA polymerase. Biochem.J., 477, 2020
5VTP	X-ray diffraction data of DNA Polymerase Eta (RAD30) of Saccharomyces cerevisiae with a single magnesium bound in absence of DNA and incoming dNTP Descriptor: DNA polymerase eta, MAGNESIUM ION Authors: Powers, K.T, Washington, M.T. Deposit date: 2017-05-17 Release date: 2018-01-24 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.8 Å) Cite: The C-terminal region of translesion synthesis DNA polymerase eta is partially unstructured and has high conformational flexibility. Nucleic Acids Res., 46, 2018
4ECV	Human DNA polymerase eta - DNA ternary complex: Reaction in the AT crystal at pH 7.0 for 230 sec Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... Authors: Nakamura, T, Zhao, Y, Yang, W. Deposit date: 2012-03-26 Release date: 2012-07-11 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.521 Å) Cite: Watching DNA polymerase eta make a phosphodiester bond Nature, 487, 2012
4ED7	Human DNA polymerase eta - DNA ternary complex: TG crystal at pH 7.0 (K+ MES) with 1 Ca2+ ion Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*G)-3'), ... Authors: Nakamura, T, Zhao, Y, Yang, W. Deposit date: 2012-03-27 Release date: 2012-07-11 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.717 Å) Cite: Watching DNA polymerase eta make a phosphodiester bond Nature, 487, 2012
4ECR	Human DNA polymerase eta - DNA ternary complex: Reaction in the AT crystal at pH 7.0 for 40 sec Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... Authors: Nakamura, T, Zhao, Y, Yang, W. Deposit date: 2012-03-26 Release date: 2012-07-11 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.892 Å) Cite: Watching DNA polymerase eta make a phosphodiester bond Nature, 487, 2012
4ECY	Human DNA polymerase eta - DNA ternary complex: AT crystal at pH 6.0 (Na+ MES) with 1 Ca2+ ion Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... Authors: Nakamura, T, Zhao, Y, Yang, W. Deposit date: 2012-03-26 Release date: 2012-07-11 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.943 Å) Cite: Watching DNA polymerase eta make a phosphodiester bond Nature, 487, 2012
4RNN	Crystal structure of human polymerase eta inserting dGMPnPP opposite DNA template containing an abasic site Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA polymerase eta, GLYCEROL, ... Authors: Patra, A, Egli, M. Deposit date: 2014-10-24 Release date: 2015-02-18 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.808 Å) Cite: Structural and Kinetic Analysis of Nucleoside Triphosphate Incorporation Opposite an Abasic Site by Human Translesion DNA Polymerase eta. J.Biol.Chem., 290, 2015
4RU9	Crystal structure of human DNA polymerase eta inserting dCMPNPP opposite a MeFapy-dG adducted DNA template Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA polymerase eta, MAGNESIUM ION, ... Authors: Patra, A, Egli, M. Deposit date: 2014-11-18 Release date: 2015-08-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structural Basis for Error-Free Bypass of the 5-N-Methylformamidopyrimidine-dG Lesion by Human DNA Polymerase eta and Sulfolobus solfataricus P2 Polymerase IV. J.Am.Chem.Soc., 137, 2015
4RNM	Crystal structure of human polymerase eta inserting dAMPnPP opposite DNA template containing an abasic site Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA Primar: AGCGTCAT, DNA Template: CAT(3DR)ATGACGCT, ... Authors: Patra, A, Egli, M. Deposit date: 2014-10-24 Release date: 2015-02-18 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.144 Å) Cite: Structural and Kinetic Analysis of Nucleoside Triphosphate Incorporation Opposite an Abasic Site by Human Translesion DNA Polymerase eta. J.Biol.Chem., 290, 2015
4RNO	Crystal structure of human polymerase eta extending an abasic site-dA pair by inserting dCTP opposite template G Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase eta, ... Authors: Patra, A, Egli, M. Deposit date: 2014-10-24 Release date: 2015-02-18 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.82 Å) Cite: Structural and Kinetic Analysis of Nucleoside Triphosphate Incorporation Opposite an Abasic Site by Human Translesion DNA Polymerase eta. J.Biol.Chem., 290, 2015

 

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