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5LDH
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BU of 5ldh by Molmil
STRUCTURE OF THE ACTIVE TERNARY COMPLEX OF PIG HEART LACTATE DEHYDROGENASE WITH S-LAC-NAD AT 2.7 ANGSTROMS RESOLUTION
Descriptor: (3S)-5-(3-CARBOXY-3-HYDROXYPROPYL) NICOTINAMIDE-ADENINE-DINUCLEOTIDE, CITRIC ACID, LACTATE DEHYDROGENASE
Authors:Grau, U.M, Rossmann, M.G.
Deposit date:1980-10-29
Release date:1981-03-04
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the active ternary complex of pig heart lactate dehydrogenase with S-lac-NAD at 2.7 A resolution.
J.Mol.Biol., 151, 1981
4M49
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BU of 4m49 by Molmil
Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 3-(5-amino-6-{[(1R)-1-phenylethyl]amino}pyrazin-2-yl)-4-chlorobenzoic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Eigenbrot, C, Ultsch, M.
Deposit date:2013-08-06
Release date:2013-09-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.052 Å)
Cite:Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase.
Bioorg.Med.Chem.Lett., 23, 2013
6Y91
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BU of 6y91 by Molmil
Crystal structure of malate dehydrogenase from Plasmodium Falciparum in complex with NADH
Descriptor: Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Romero, A.R, Calderone, V, Gentili, M, Lunev, S, Groves, M, Popowicz, G, Domling, A, Sattler, M.
Deposit date:2020-03-06
Release date:2021-03-31
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity.
Commun Biol, 4, 2021
7NRZ
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BU of 7nrz by Molmil
Crystal structure of malate dehydrogenase from Trypanosoma cruzi
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Sonani, R.R, Kurpiewska, K, Lewinski, K, Dubin, G.
Deposit date:2021-03-04
Release date:2022-02-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Distinct sequence and structural feature of trypanosoma malate dehydrogenase.
Biochem.Biophys.Res.Commun., 557, 2021
3ZH2
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Structure of Plasmodium falciparum lactate dehydrogenase in complex with a DNA aptamer
Descriptor: DNA APTAMER, L-LACTATE DEHYDROGENASE
Authors:Cheung, Y.W, Kwok, J, Law, A.W.L, Watt, R.M, Kotaka, M, Tanner, J.A.
Deposit date:2012-12-20
Release date:2013-09-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for Discriminatory Recognition of Plasmodium Lactate Dehydrogenase by a DNA Aptamer
Proc.Natl.Acad.Sci.USA, 110, 2013
8J5D
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BU of 8j5d by Molmil
Cryo-EM structure of starch degradation complex of BAM1-LSF1-MDH
Descriptor: Beta-amylase 1, chloroplastic, Malate dehydrogenase, ...
Authors:Guan, Z.Y, Liu, J, Yan, J.J.
Deposit date:2023-04-21
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (3 Å)
Cite:The LIKE SEX FOUR 1-malate dehydrogenase complex functions as a scaffold to recruit beta-amylase to promote starch degradation.
Plant Cell, 36, 2023
6PBL
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BU of 6pbl by Molmil
Crystal structure of Malate dehydrogenase from Legionella pneumophila Philadelphia 1
Descriptor: Malate dehydrogenase
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2019-06-14
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of Malate dehydrogenase from Legionella pneumophila Philadelphia 1
TO BE PUBLISHED
6TXR
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BU of 6txr by Molmil
Structural insights into cubane-modified aptamer recognition of a malaria biomarker
Descriptor: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, ...
Authors:Cheung, Y, Roethlisberger, P, Mechaly, A, Weber, P, Wong, A, Lo, Y, Haouz, A, Savage, P, Hollenstein, M, Tanner, J.
Deposit date:2020-01-14
Release date:2020-07-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker.
Proc.Natl.Acad.Sci.USA, 117, 2020
5ES3
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BU of 5es3 by Molmil
Co-crystal structure of LDH liganded with oxamate
Descriptor: L-lactate dehydrogenase A chain, OXAMIC ACID
Authors:Nowicki, M.W, Wear, M.A, McNae, I.W, Blackburn, E.A.
Deposit date:2015-11-16
Release date:2016-01-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:A Streamlined, Automated Protocol for the Production of Milligram Quantities of Untagged Recombinant Rat Lactate Dehydrogenase A Using AKTAxpressTM.
Plos One, 10, 2015
8LDH
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BU of 8ldh by Molmil
REFINED CRYSTAL STRUCTURE OF DOGFISH M4 APO-LACTATE DEHYDROGENASE
Descriptor: CITRIC ACID, M4 APO-LACTATE DEHYDROGENASE
Authors:Abad-Zapatero, C, Rossmann, M.G.
Deposit date:1988-01-04
Release date:1989-07-12
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Refined crystal structure of dogfish M4 apo-lactate dehydrogenase.
J.Mol.Biol., 198, 1987
6CT6
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BU of 6ct6 by Molmil
Crystal structure of lactate dehydrogenase from Eimeria maxima with NADH and oxamate
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Lactate dehydrogenase, OXAMIC ACID, ...
Authors:Wirth, J.D, Xu, C, Theobald, D.L.
Deposit date:2018-03-22
Release date:2019-03-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.705 Å)
Cite:The Mechanistic, Structural, and Evolutionary Origin of Lactate Dehydrogenase Substrate Specificity in Apicomplexa
To Be Published
7P4G
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BU of 7p4g by Molmil
Rabbit Muscle L-lactate dehydrogenase in complex with citrate
Descriptor: CITRIC ACID, L-lactate dehydrogenase A chain
Authors:Iacovino, L.G, Binda, C, Hochkoeppler, A.
Deposit date:2021-07-11
Release date:2022-05-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Allosteric transitions of rabbit skeletal muscle lactate dehydrogenase induced by pH-dependent dissociation of the tetrameric enzyme.
Biochimie, 199, 2022
6ZZR
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BU of 6zzr by Molmil
The Crystal Structure of human LDHA from Biortus.
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, L-lactate dehydrogenase A chain
Authors:Wang, F, Lin, D, Cheng, W, Bao, X, Zhu, B, Shang, H.
Deposit date:2020-08-05
Release date:2020-08-19
Last modified:2024-04-24
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The Crystal Structure of human LDHA from Biortus
To Be Published
3LDH
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BU of 3ldh by Molmil
A comparison of the structures of apo dogfish m4 lactate dehydrogenase and its ternary complexes
Descriptor: LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PYRUVIC ACID
Authors:White, J.L, Hackert, M.L, Buehner, M, Adams, M.J, Ford, G.C, Lentzjunior, P.J, Smiley, I.E, Steindel, S.J, Rossmann, M.G.
Deposit date:1974-06-06
Release date:1977-04-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:A comparison of the structures of apo dogfish M4 lactate dehydrogenase and its ternary complexes.
J.Mol.Biol., 102, 1976
7Q3X
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BU of 7q3x by Molmil
Crystal structure of Malate dehydrogenase from Haloarcula marismortui with Potassium and Chloride ions
Descriptor: CHLORIDE ION, Malate dehydrogenase, POTASSIUM ION
Authors:Bertrand, Q, Roche, J, Girard, E, Madern, D.
Deposit date:2021-10-29
Release date:2022-02-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Resurrection of Ancestral Malate Dehydrogenases Reveals the Evolutionary History of Haloarchaeal Proteins.
To Be Published
1EMD
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BU of 1emd by Molmil
CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF ESCHERICHIA COLI MALATE DEHYDROGENASE, CITRATE AND NAD AT 1.9 ANGSTROMS RESOLUTION
Descriptor: CITRIC ACID, MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Hall, M.D, Banaszak, L.J.
Deposit date:1993-03-25
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a ternary complex of Escherichia coli malate dehydrogenase citrate and NAD at 1.9 A resolution.
J.Mol.Biol., 232, 1993
7AOB
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BU of 7aob by Molmil
Crystal structure of Thermaerobacter marianensis malate dehydrogenase
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Bertrand, Q, Lasalle, L, Girard, E, Madern, D.
Deposit date:2020-10-14
Release date:2020-10-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Crystal structure of Thermaerobacter marianensis malate dehydrogenase
To Be Published
8Q3C
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BU of 8q3c by Molmil
Structure of Selenomonas ruminantium lactate dehydrogenase I85R mutant
Descriptor: CHLORIDE ION, L-lactate dehydrogenase, NITRATE ION, ...
Authors:Bertrand, Q, Coquille, S, Iorio, A, Sterpone, F, Madern, D.
Deposit date:2023-08-03
Release date:2023-11-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Biochemical, structural and dynamical characterizations of the lactate dehydrogenase from Selenomonas ruminantium provide information about an intermediate evolutionary step prior to complete allosteric regulation acquisition in the super family of lactate and malate dehydrogenases.
J.Struct.Biol., 215, 2023
6H9S
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BU of 6h9s by Molmil
Crystal dimeric structure of Petrotoga mobilis lactate dehydrogenase with NADH
Descriptor: L-lactate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Roche, J, Engilberge, S, Girard, E, Madern, D.
Deposit date:2018-08-06
Release date:2018-08-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of Petrotoga mobilis lactate dehydrogenase at 1.9 Angstrom resolution
To Be Published
1EZ4
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BU of 1ez4 by Molmil
CRYSTAL STRUCTURE OF NON-ALLOSTERIC L-LACTATE DEHYDROGENASE FROM LACTOBACILLUS PENTOSUS AT 2.3 ANGSTROM RESOLUTION
Descriptor: LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Uchikoba, H, Fushinobu, S, Wakagi, T, Konno, M, Taguchi, H, Matsuzawa, H.
Deposit date:2000-05-10
Release date:2001-12-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of non-allosteric L-lactate dehydrogenase from Lactobacillus pentosus at 2.3 A resolution: specific interactions at subunit interfaces.
Proteins, 46, 2002
5A1T
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BU of 5a1t by Molmil
Trichomonas vaginalis lactate dehydrogenase in complex with NADH and oxamate
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, L-LACTATE DEHYDROGENASE, OXAMIC ACID
Authors:Steindel, P.A, Chen, E.H, Theobald, D.L.
Deposit date:2015-05-05
Release date:2016-03-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Gradual Neofunctionalization in the Convergent Evolution of Trichomonad Lactate and Malate Dehydrogenases.
Protein Sci., 25, 2016
6CEP
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BU of 6cep by Molmil
Sus scrofa heart L-lactate dehydrogenase ternary complex with NADH and oxamate
Descriptor: L-lactate dehydrogenase B chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID
Authors:Hoffer, E.D, Andrews, B, Dunham, C.M, Dyer, R.B.
Deposit date:2018-02-12
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Small molecule cores demonstrate non-competitive inhibition of lactate dehydrogenase.
Medchemcomm, 9, 2018
6ITL
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BU of 6itl by Molmil
Crystal structure of malate dehydrogenase from Mannheimia succiniciproducens in complex with NAD
Descriptor: GLYCEROL, Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Seo, H, Kim, K.-J.
Deposit date:2018-11-23
Release date:2019-11-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase.
Nat Commun, 11, 2020
4H7P
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BU of 4h7p by Molmil
Crystal structure of a putative Cytosolic malate dehydrogenase from Leishmania major Friedlin
Descriptor: Malate dehydrogenase, SULFATE ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2012-09-20
Release date:2012-10-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of a putative Cytosolic malate dehydrogenase from Leishmania major Friedlin
To be Published
4ZVV
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Lactate dehydrogenase A in complex with a trisubstituted piperidine-2,4-dione inhibitor GNE-140
Descriptor: (2~{R})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one, L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Li, Y, Chen, Z, Eigenbrot, C.
Deposit date:2015-05-18
Release date:2016-05-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.
Nat.Chem.Biol., 12, 2016

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數據於2024-06-26公開中

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