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5IXY

Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 31: (2~{S})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one

Summary for 5IXY
Entry DOI10.2210/pdb5ixy/pdb
Related5IXS
DescriptorL-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION, ... (4 entities in total)
Functional Keywordsoxidoreductase tetramer, oxireductase-oxireductase inhibitor complex, oxireductase/oxireductase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: P00338
Total number of polymer chains4
Total formula weight151736.21
Authors
Chen, Z.,Eigenbrot, C. (deposition date: 2016-03-23, release date: 2016-09-14, Last modification date: 2023-09-27)
Primary citationPurkey, H.E.,Robarge, K.,Chen, J.,Chen, Z.,Corson, L.B.,Ding, C.Z.,DiPasquale, A.G.,Dragovich, P.S.,Eigenbrot, C.,Evangelista, M.,Fauber, B.P.,Gao, Z.,Ge, H.,Hitz, A.,Ho, Q.,Labadie, S.S.,Lai, K.W.,Liu, W.,Liu, Y.,Li, C.,Ma, S.,Malek, S.,O'Brien, T.,Pang, J.,Peterson, D.,Salphati, L.,Sideris, S.,Ultsch, M.,Wei, B.,Yen, I.,Yue, Q.,Zhang, H.,Zhou, A.
Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice.
Acs Med.Chem.Lett., 7:896-901, 2016
Cited by
PubMed: 27774125
DOI: 10.1021/acsmedchemlett.6b00190
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

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