5IXS

Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 9: (6R)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one

Summary for 5IXS

Entry DOI	10.2210/pdb5ixs/pdb
Related	5IXY
Descriptor	L-lactate dehydrogenase A chain, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... (7 entities in total)
Functional Keywords	oxidoreductase tetramer, oxireductase-oxireductase inhibitor complex, oxireductase/oxireductase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P00338
Total number of polymer chains	4
Total formula weight	151900.63
Authors	Ultsch, M.,Eigenbrot, C. (deposition date: 2016-03-23, release date: 2016-09-14, Last modification date: 2023-09-27)
Primary citation	Purkey, H.E.,Robarge, K.,Chen, J.,Chen, Z.,Corson, L.B.,Ding, C.Z.,DiPasquale, A.G.,Dragovich, P.S.,Eigenbrot, C.,Evangelista, M.,Fauber, B.P.,Gao, Z.,Ge, H.,Hitz, A.,Ho, Q.,Labadie, S.S.,Lai, K.W.,Liu, W.,Liu, Y.,Li, C.,Ma, S.,Malek, S.,O'Brien, T.,Pang, J.,Peterson, D.,Salphati, L.,Sideris, S.,Ultsch, M.,Wei, B.,Yen, I.,Yue, Q.,Zhang, H.,Zhou, A. Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. Acs Med.Chem.Lett., 7:896-901, 2016 Cited by PubMed: 27774125 DOI: 10.1021/acsmedchemlett.6b00190 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation