PDB: 4362 resultsInfo pagesStatus searchChemie searchBIRD

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2AV7	Crystal structure of HTLV-1 TAX peptide Bound to Human Class I MHC HLA-A2 with the K66A mutation in the heavy chain. Descriptor: Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... Authors: Borbulevych, O.Y, Baker, B.M. Deposit date: 2005-08-29 Release date: 2005-10-18 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Unraveling a Hotspot for TCR Recognition on HLA-A2: Evidence Against the Existence of Peptide-independent TCR Binding Determinants. J.Mol.Biol., 353, 2005
3JQL	Crystal Structure of the Complex Formed Between Phospholipase A2 and a Hexapeptide Fragment of Amyloid Beta Peptide, Lys-Leu-Val-Phe-Phe-Ala at 1.2 A Resolution Descriptor: Acidic phospholipase A2 3 (Fragment), Amyloid Beta Peptide, CALCIUM ION Authors: Mirza, Z, Vikram, G, Singh, N, Sinha, M, Sharma, S, Srinivasan, A, Kaur, P, Singh, T.P. Deposit date: 2009-09-07 Release date: 2009-09-29 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Crystal Structure of the Complex Formed Between Phospholipase A2 and a Hexapeptide Fragment of Amyloid Beta Peptide, Lys-Leu-Val-Phe-Phe-Ala at 1.2 A Resolution To be Published
3JTI	Crystal structure of the complex formed between Phospholipase A2 with beta-amyloid fragment, Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met at 1.8 A resolution Descriptor: CALCIUM ION, Phospholipase A2 isoform 3, octapeptide from Amyloid beta A4 protein Authors: Pandey, N, Mirza, Z, Vikram, G, Singh, N, Bhushan, A, Kaur, P, Srinivasan, A, Sharma, S, Singh, T.P. Deposit date: 2009-09-12 Release date: 2010-07-21 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of the complex formed between Phospholipase A2 with beta-amyloid fragment, Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met at 1.8 A resolution To be Published
2AV1	Crystal structure of HTLV-1 TAX peptide Bound to Human Class I MHC HLA-A2 with the E63Q and K66A mutations in the heavy chain. Descriptor: Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... Authors: Borbulevych, O.Y, Baker, B.M. Deposit date: 2005-08-29 Release date: 2005-10-18 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Unraveling a Hotspot for TCR Recognition on HLA-A2: Evidence Against the Existence of Peptide-independent TCR Binding Determinants. J.Mol.Biol., 353, 2005
1KMF	NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-ALLO-ILE, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES Descriptor: Insulin Authors: Xu, B, Hua, Q.X, Nakagawa, S.H, Jia, W, Chu, Y.C, Katsoyannis, P.G, Weiss, M.A. Deposit date: 2001-12-14 Release date: 2002-01-09 Last modified: 2024-11-06 Method: SOLUTION NMR Cite: Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue. J.Mol.Biol., 316, 2002
4QMC	Crystal structure of complex formed between phospholipase A2 and Biotin-sulfoxide at 1.09 A Resolution Descriptor: ACETATE ION, BIOTIN-D-SULFOXIDE, GLYCEROL, ... Authors: Shukla, P.K, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. Deposit date: 2014-06-16 Release date: 2014-07-30 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.09 Å) Cite: Crystal structure of complex formed between phospholipase A2 and Biotin-sulfoxide at 1.09 A Resolution To be published
5IRO	Crystal structure of a complex between the Human adenovirus type 4 E3-19K protein and MHC class molecule HLA-A2/TAX Descriptor: Beta-2-microglobulin, E3 19 kDa protein, HLA class I histocompatibility antigen, ... Authors: Li, L, Bouvier, M. Deposit date: 2016-03-14 Release date: 2016-08-24 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.64 Å) Cite: Structure of the Adenovirus Type 4 (Species E) E3-19K/HLA-A2 Complex Reveals Species-Specific Features in MHC Class I Recognition. J Immunol., 197, 2016
1SQZ	Design of specific inhibitors of Phopholipase A2: Crystal structure of the complex formed between Group II Phopholipase A2 and a designed peptide Dehydro-Ile-Ala-Arg-Ser at 1.2A resolution Descriptor: Phospholipase A2, SULFATE ION, synthetic peptide Authors: Singh, N, Prem Kumar, R, Somvanshi, R.K, Bilgrami, S, Ethayathulla, A.S, Sharma, S, Dey, S, Singh, T.P. Deposit date: 2004-03-22 Release date: 2004-04-13 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Design of specific inhibitors of Phopholipase A2: Crystal structure of the complex formed between GroupII Phopholipase A2 and a designed peptide Dehydro-Ile-Ala-Arg-Ser at 1.2A resolution To be Published
1C74	Structure of the double mutant (K53,56M) of phospholipase A2 Descriptor: CALCIUM ION, PHOSPHOLIPASE A2 Authors: Sekar, K, Tsai, M.D, Jain, M.K, Ramakumar, S. Deposit date: 2000-01-22 Release date: 2000-07-22 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural basis of the anionic interface preference and k*cat activation of pancreatic phospholipase A2. Biochemistry, 39, 2000
2DPZ	Structure of the complex of phospholipase A2 with N-(4-hydroxyphenyl)- acetamide at 2.1 A resolution Descriptor: N-(4-HYDROXYPHENYL)ACETAMIDE (TYLENOL), Phospholipase A2 VRV-PL-VIIIa, SULFATE ION Authors: Singh, N, Sharma, S, Singh, T.P. Deposit date: 2006-05-18 Release date: 2006-06-06 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Phospholipase A2 as a target protein for non-steroidal anti-inflammatory drugs (NSAIDs): Crystal structure of the complex formed between a group II phospholipase A2 and N-(4-hydroxyphenyl) - acetamide at 2.1 resolution To be Published
1TD7	Interactions of a specific non-steroidal anti-inflammatory drug (NSAID) with group I phospholipase A2 (PLA2): Crystal structure of the complex formed between PLA2 and niflumic acid at 2.5 A resolution Descriptor: 2-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}NICOTINIC ACID, CALCIUM ION, Phospholipase A2 isoform 3 Authors: Jabeen, T, Singh, N, Singh, R.K, Sharma, S, Perbandt, M, Betzel, C, Singh, T.P. Deposit date: 2004-05-21 Release date: 2004-06-08 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Non-steroidal anti-inflammatory drugs as potent inhibitors of phospholipase A2: structure of the complex of phospholipase A2 with niflumic acid at 2.5 Angstroms resolution. Acta Crystallogr.,Sect.D, 61, 2005
4GLD	Crystal Structure of the complex of type II phospholipase A2 with a designed peptide inhibitor Phe - Leu - Ala - Tyr - Lys at 1.69 A resolution Descriptor: ACETATE ION, FLAYK, Phospholipase A2 VRV-PL-VIIIa, ... Authors: Shukla, P.K, Sinha, M, Dey, S, Kaur, P, Sharma, S, Singh, T.P. Deposit date: 2012-08-14 Release date: 2012-08-29 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Crystal Structure of the complex of type II phospholipase A2 with a designed peptide inhibitor Phe - Leu - Ala - Tyr - Lys at 1.69 A resolution To be Published
3H1X	Simultaneous inhibition of anti-coagulation and inflammation: Crystal structure of phospholipase A2 complexed with indomethacin at 1.4 A resolution reveals the presence of the new common ligand binding site Descriptor: INDOMETHACIN, Phospholipase A2 VRV-PL-VIIIa, SULFATE ION Authors: Singh, N, Prem Kumar, R, Sharma, S, Kaur, P, Singh, T.P. Deposit date: 2009-04-14 Release date: 2009-06-09 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Simultaneous inhibition of anti-coagulation and inflammation: crystal structure of phospholipase A2 complexed with indomethacin at 1.4 A resolution reveals the presence of the new common ligand-binding site J.Mol.Recognit., 22, 2009
1KQU	Human phospholipase A2 complexed with a substrate anologue Descriptor: 6-PHENYL-4(R)-(7-PHENYL-HEPTANOYLAMINO)-HEXANOIC ACID, CALCIUM ION, Phospholipase A2, ... Authors: Tyndall, J.D, Martin, J.L. Deposit date: 2002-01-07 Release date: 2003-11-11 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity. Chembiochem, 4, 2003
3FG5	Crystal structure determination of a ternary complex of phospholipase A2 with a pentapeptide FLSYK and Ajmaline at 2.5 A resolution Descriptor: AJMALINE, Group II Phospholipase A2, pentapeptide FLSYK Authors: Kumar, M, Kumar, S, Vikram, G, Singh, N, Sinha, M, Bhushan, A, Kaur, P, Srinivasan, A, Sharma, S, Singh, T.P. Deposit date: 2008-12-05 Release date: 2008-12-23 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure determination of a ternary complex of phospholipase A2 with a pentapeptide FLSYK and Ajmaline at 2.5 A resolution To be Published
2GT9	Human Class I MHC HLA-A2 in complex with the decameric Melan-A/MART-1(26-35) peptide Descriptor: Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... Authors: Borbulevych, O.Y, Baker, B.M. Deposit date: 2006-04-27 Release date: 2007-06-12 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structures of MART-1(26/27-35) Peptide/HLA-A2 Complexes Reveal a Remarkable Disconnect between Antigen Structural Homology and T Cell Recognition J.Mol.Biol., 372, 2007
2GTW	Human Class I MHC HLA-A2 in complex with the nonameric Melan-A/MART-1(27-35) peptide having A27L substitution Descriptor: Beta-2-microglobulin, FORMIC ACID, GLYCEROL, ... Authors: Borbulevych, O.Y, Baker, B.M. Deposit date: 2006-04-28 Release date: 2007-06-12 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.548 Å) Cite: Structures of MART-1(26/27-35) Peptide/HLA-A2 Complexes Reveal a Remarkable Disconnect between Antigen Structural Homology and T Cell Recognition J.Mol.Biol., 372, 2007
8GQQ	The three-dimensional structure of Cystatin A2, a cysteine protease inhibitor from Dictyostelium discoideum Descriptor: Cystatin-A2 Authors: Dinh, T.T, Dao, O, Lee, K.H. Deposit date: 2022-08-30 Release date: 2023-09-06 Method: X-RAY DIFFRACTION (1.069 Å) Cite: The three-dimensional structure of Cystatin A2, a cysteine protease inhibitor from Dictyostelium discoideum To Be Published
1MF4	Structure-based design of potent and selective inhibitors of phospholipase A2: Crystal structure of the complex formed between phosholipase A2 from Naja Naja sagittifera and a designed peptide inhibitor at 1.9 A resolution Descriptor: CALCIUM ION, Phospholipase A2, VAL-ALA-PHE-ARG-SER Authors: Singh, R.K, Vikram, P, Paramsivam, M, Jabeen, T, Sharma, S, Makker, J, Dey, S, Kaur, P, Srinivasan, A, Singh, T.P. Deposit date: 2002-08-09 Release date: 2003-09-30 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Design of specific peptide inhibitors for group I phospholipase A2: structure of a complex formed between phospholipase A2 from Naja naja sagittifera (group I) and a designed peptide inhibitor Val-Ala-Phe-Arg-Ser (VAFRS) at 1.9 A resolution reveals unique features Biochemistry, 42, 2003
5JAO	Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered Through X-Ray Fragment Screening Descriptor: 2'-chloro-6-methyl[1,1'-biphenyl]-3-amine, CALCIUM ION, CHLORIDE ION, ... Authors: Day, P.J. Deposit date: 2016-04-12 Release date: 2016-05-25 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening. J.Med.Chem., 59, 2016
5JAP	Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered Through X-Ray Fragment Screening Descriptor: (2,5-dihydro-1H-pyrrol-1-yl)(2',6-dimethyl[1,1'-biphenyl]-3-yl)methanone, CALCIUM ION, CHLORIDE ION, ... Authors: Day, P.J. Deposit date: 2016-04-12 Release date: 2016-05-25 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.46 Å) Cite: Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening. J.Med.Chem., 59, 2016
2DO2	Design of specific inhibitors of phospholipase A2: Crystal structure of the complex formed between a group II Cys 49 phospholipase A2 and a designed pentapeptide Ala-Leu-Ala-Ser-Lys at 2.6A resolution Descriptor: Ala-Leu-Ala-Ser-Lys, Phospholipase A2 VRV-PL-VIIIa, SULFATE ION Authors: Singh, N, Sharma, S, Somvanshi, R.K, Dey, S, Singh, T.P. Deposit date: 2006-04-27 Release date: 2006-05-16 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Design of specific inhibitors of phospholipase A2: Crystal structure of the complex formed between a group II Cys 49 phospholipase A2 and a designed pentapeptide Ala-Leu-Ala-Ser-Lys at 2.6A resolution To be Published
2I0U	Crystal structures of phospholipases A2 from Vipera nikolskii venom revealing Triton X-100 bound in hydrophobic channel Descriptor: Basic subunit of heterodimer phospholipase A2, CALCIUM ION, FRAGMENT OF TRITON X-100, ... Authors: Gao, W, Bi, R.C. Deposit date: 2006-08-11 Release date: 2007-09-11 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structures of phospholipases A2 from Vipera nikolskii venom revealing Triton X-100 bound in hydrophobic channel To be Published
2G58	Crystal structure of a complex of phospholipase A2 with a designed peptide inhibitor Dehydro-Ile-Ala-Arg-Ser at 0.98 A resolution Descriptor: (PHQ)IARS, Phospholipase A2 VRV-PL-VIIIa, SULFATE ION Authors: Prem Kumar, R, Singh, N, Somvanshi, R.K, Ethayathulla, A.S, Dey, S, Sharma, S, Kaur, P, Perbandt, M, Betzel, C, Singh, T.P. Deposit date: 2006-02-22 Release date: 2006-03-28 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (0.98 Å) Cite: Crystal structure of a complex of phospholipase A2 with a designed peptide inhibitor Dehydro-Ile-Ala-Arg-Ser at 0.98 A resolution To be Published
2GTZ	Human Class I MHC HLA-A2 in complex with the nonameric Melan-A/MART-1(27-35) peptide having A28L substitution Descriptor: Beta-2-microglobulin, GLYCEROL, HLA-A*0201 heavy chain, ... Authors: Borbulevych, O.Y, Baker, B.M. Deposit date: 2006-04-28 Release date: 2007-06-12 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structures of MART-1(26/27-35) Peptide/HLA-A2 Complexes Reveal a Remarkable Disconnect between Antigen Structural Homology and T Cell Recognition J.Mol.Biol., 372, 2007

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