3SFK
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![BU of 3sfk by Molmil](/molmil-images/mine/3sfk) | Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM267 | Descriptor: | 2-(1,1-difluoroethyl)-5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | Authors: | Deng, X, Phillips, M. | Deposit date: | 2011-06-13 | Release date: | 2011-07-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential. J.Med.Chem., 54, 2011
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3MJY
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![BU of 3mjy by Molmil](/molmil-images/mine/3mjy) | Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Aminoorotic acid | Descriptor: | 5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... | Authors: | Pinheiro, M.P, Rocha, J.R, Cheleski, J, Montanari, C.A, Nonato, M.C. | Deposit date: | 2010-04-13 | Release date: | 2011-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery. Eur.J.Med.Chem., 45, 2010
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3MHU
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![BU of 3mhu by Molmil](/molmil-images/mine/3mhu) | Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Nitroorotic acid | Descriptor: | 5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... | Authors: | Pinheiro, M.P, Rocha, J.R, Cheleski, J, Montanari, C.A, Nonato, M.C. | Deposit date: | 2010-04-08 | Release date: | 2011-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery. Eur.J.Med.Chem., 45, 2010
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3OIX
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![BU of 3oix by Molmil](/molmil-images/mine/3oix) | Crystal structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans | Descriptor: | FLAVIN MONONUCLEOTIDE, GLYCEROL, Putative dihydroorotate dehydrogenase; dihydroorotate oxidase | Authors: | Liu, Y, Gao, Z.Q, Liu, C.P, Dong, Y.H. | Deposit date: | 2010-08-20 | Release date: | 2010-09-08 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.399 Å) | Cite: | Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans Acta Crystallogr.,Sect.F, 67, 2011
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2WV8
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![BU of 2wv8 by Molmil](/molmil-images/mine/2wv8) | Complex of human dihydroorotate dehydrogenase with the inhibitor 221290 | Descriptor: | 2-ACETAMIDO-5-(4-PHENYLPHENYL)BENZOIC ACID, ACETATE ION, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, ... | Authors: | Walse, B, Svensson, B, Fritzson, I, Dahlberg, L, Wellmar, U, Al-Karadaghi, S. | Deposit date: | 2009-10-15 | Release date: | 2010-08-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Inhibition of Human Dhodh by 4-Hydroxycoumarins, Fenamic Acids, and N-(Alkylcarbonyl)Anthranilic Acids Identified by Structure-Guided Fragment Selection. Chemmedchem, 5, 2010
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3O8A
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![BU of 3o8a by Molmil](/molmil-images/mine/3o8a) | Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with novel Inhibitor Genz667348 | Descriptor: | Dihydroorotate dehydrogenase homolog, mitochondrial, FLAVIN MONONUCLEOTIDE, ... | Authors: | Deng, X, Booker, M.L, Phillips, M.A. | Deposit date: | 2010-08-02 | Release date: | 2010-08-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. J.Biol.Chem., 285, 2010
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3GZ3
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![BU of 3gz3 by Molmil](/molmil-images/mine/3gz3) | |
3GYE
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![BU of 3gye by Molmil](/molmil-images/mine/3gye) | |
3KVL
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![BU of 3kvl by Molmil](/molmil-images/mine/3kvl) | |
3KVM
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![BU of 3kvm by Molmil](/molmil-images/mine/3kvm) | |
3KVK
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![BU of 3kvk by Molmil](/molmil-images/mine/3kvk) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with amino-benzoic acid inhibitor 641 at 2.05A resolution | Descriptor: | (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, 2-{[(3,5-dichlorophenyl)carbamoyl]amino}benzoic acid, Dihydroorotate dehydrogenase, ... | Authors: | McLean, L, Zhang, Y. | Deposit date: | 2009-11-30 | Release date: | 2010-03-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Discovery of novel inhibitors for DHODH via virtual screening and X-ray crystallographic structures. Bioorg.Med.Chem.Lett., 20, 2010
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3KVJ
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![BU of 3kvj by Molmil](/molmil-images/mine/3kvj) | |
3I65
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![BU of 3i65 by Molmil](/molmil-images/mine/3i65) | Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM1 | Descriptor: | 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, Dihydroorotate dehydrogenase homolog, mitochondrial, ... | Authors: | Deng, X, Phillips, M.A. | Deposit date: | 2009-07-06 | Release date: | 2009-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds. J.Biol.Chem., 284, 2009
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3I68
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![BU of 3i68 by Molmil](/molmil-images/mine/3i68) | |
3I6R
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![BU of 3i6r by Molmil](/molmil-images/mine/3i6r) | Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM74 | Descriptor: | 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, Dihydroorotate dehydrogenase homolog, mitochondrial, ... | Authors: | Deng, X, Phillips, M.A. | Deposit date: | 2009-07-07 | Release date: | 2009-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds. J.Biol.Chem., 284, 2009
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3F1Q
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![BU of 3f1q by Molmil](/molmil-images/mine/3f1q) | Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 1 | Descriptor: | (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide, ACETIC ACID, Dihydroorotate dehydrogenase, ... | Authors: | Heikkila, T, Davies, M, McConkey, G.A, Fishwick, C.W.G, Parsons, M.R, Johnson, A.P. | Deposit date: | 2008-10-28 | Release date: | 2009-06-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52, 2009
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3FJ6
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![BU of 3fj6 by Molmil](/molmil-images/mine/3fj6) | Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 2 | Descriptor: | (2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide, ACETATE ION, Dihydroorotate dehydrogenase, ... | Authors: | Heikkila, T. | Deposit date: | 2008-12-14 | Release date: | 2009-06-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52, 2009
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3FJL
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![BU of 3fjl by Molmil](/molmil-images/mine/3fjl) | |
3G0U
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![BU of 3g0u by Molmil](/molmil-images/mine/3g0u) | Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 4 | Descriptor: | (2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... | Authors: | Davis, M, Heikkila, T, McConkey, G.A, Fishwick, C.W.G, Parsons, M.R, Johnson, A.P. | Deposit date: | 2009-01-28 | Release date: | 2009-06-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52, 2009
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3G0X
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![BU of 3g0x by Molmil](/molmil-images/mine/3g0x) | Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 5 | Descriptor: | (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... | Authors: | Davies, M, Heikkila, T, McConkey, G.A, Fishwick, C.W.G, Parsons, M.R, Johnson, A.P. | Deposit date: | 2009-01-29 | Release date: | 2009-06-09 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52, 2009
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2PRM
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![BU of 2prm by Molmil](/molmil-images/mine/2prm) | The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site | Descriptor: | Dihydroorotate dehydrogenase, mitochondrial, FLAVIN MONONUCLEOTIDE, ... | Authors: | Walse, B, Dufe, V.T, Al-Karadaghi, S. | Deposit date: | 2007-05-04 | Release date: | 2008-05-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites Biochemistry, 47, 2008
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2PRL
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![BU of 2prl by Molmil](/molmil-images/mine/2prl) | The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site | Descriptor: | 5-METHOXY-2-[(4-PHENOXYPHENYL)AMINO]BENZOIC ACID, ACETATE ION, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, ... | Authors: | Walse, B, Dufe, V.T, Al-Karadaghi, S. | Deposit date: | 2007-05-04 | Release date: | 2008-05-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites Biochemistry, 47, 2008
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2PRH
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![BU of 2prh by Molmil](/molmil-images/mine/2prh) | The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site | Descriptor: | 6-CHLORO-2-(2'-FLUOROBIPHENYL-4-YL)-3-METHYLQUINOLINE-4-CARBOXYLIC ACID, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, Dihydroorotate dehydrogenase, ... | Authors: | Walse, B, Dufe, V.T, Al-Karadaghi, S. | Deposit date: | 2007-05-04 | Release date: | 2008-05-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites Biochemistry, 47, 2008
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3C3N
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![BU of 3c3n by Molmil](/molmil-images/mine/3c3n) | Crystal structure of dihydroorotate dehydrogenase from Trypanosoma cruzi strain Y | Descriptor: | Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | Authors: | Pinheiro, M.P, Iulek, J, Nonato, M.C. | Deposit date: | 2008-01-28 | Release date: | 2008-04-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase from Y strain Biochem.Biophys.Res.Commun., 369, 2008
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3C61
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![BU of 3c61 by Molmil](/molmil-images/mine/3c61) | Crystal structure of dihydroorotate dehydrogenase from Leishmania donovani | Descriptor: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, AZIDE ION, CHLORIDE ION, ... | Authors: | Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP) | Deposit date: | 2008-02-01 | Release date: | 2008-02-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Dihydroorotate dehydrogenase from Leishmania donovani. To be Published
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