3FJL

Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 3

Summary for 3FJL
Related3F1Q 3FJ6
DescriptorDihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (7 entities in total)
Functional Keywordsalpha-beta barrel, tim barrel, fad, flavoprotein, membrane, mitochondrion, mitochondrion inner membrane, oxidoreductase, polymorphism, pyrimidine biosynthesis, transit peptide
Biological sourceHomo sapiens (human)
Cellular locationMitochondrion inner membrane; Single-pass membrane protein: Q02127
Total number of polymer chains1
Total formula weight41007.50
Authors
Heikkila, T. (deposition date: 2008-12-14, release date: 2009-06-09, Last modification date: 2011-07-13)
Primary citationDavies, M.,Fishwick, C.W.G.,Heikkila, T.,Johnson, A.P.,McConkey, G.A.,Parsons, M.R.
Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases
J.Med.Chem., 52:2683-2693, 2009
PubMed: 19351152
DOI: 110.1021/jm800963t
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation
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PDB entries from 2021-06-09