2WV8

Complex of human dihydroorotate dehydrogenase with the inhibitor 221290

Summary for 2WV8

Entry DOI	10.2210/pdb2wv8/pdb
Related	1D3G 1D3H 2B0M 2BXV
Descriptor	DIHYDROOROTATE DEHYDROGENASE, MITOCHONDRIAL, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (8 entities in total)
Functional Keywords	flavoprotein, transmembrane, mitochondrion inner membrane, oxidoreductase, transit peptide, enzyme inhibition, pyrimidine biosynthesis, structure-based drug design, inflamation
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Mitochondrion inner membrane ; Single-pass membrane protein : Q02127
Total number of polymer chains	1
Total formula weight	40954.53
Authors	Walse, B.,Svensson, B.,Fritzson, I.,Dahlberg, L.,Wellmar, U.,Al-Karadaghi, S. (deposition date: 2009-10-15, release date: 2010-08-25, Last modification date: 2018-01-17)
Primary citation	Fritzson, I.,Svensson, B.,Al-Karadaghi, S.,Walse, B.,Wellmar, U.,Nilsson, U.J.,Da Graca Thrige, D.,Jonsson, S. Inhibition of Human Dhodh by 4-Hydroxycoumarins, Fenamic Acids, and N-(Alkylcarbonyl)Anthranilic Acids Identified by Structure-Guided Fragment Selection. Chemmedchem, 5:608-, 2010 Cited by PubMed: 20183850 DOI: 10.1002/CMDC.200900454 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation