1D3H

HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH ANTIPROLIFERATIVE AGENT A771726

Summary for 1D3H

Related1D3G
DescriptorDIHYDROOROTATE DEHYDROGENASE, SULFATE ION, ACETATE ION, ... (7 entities in total)
Functional Keywordsalpha-beta barrel, membrane binding motif, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationMitochondrion inner membrane; Single-pass membrane protein Q02127
Total number of polymer chains1
Total molecular weight40894.29
Authors
Liu, S.,Neidhardt, E.A.,Grossman, T.H.,Ocain, T.,Clardy, J. (deposition date: 1999-09-29, release date: 2000-08-13, Last modification date: 2012-07-18)
Primary citation
Liu, S.,Neidhardt, E.A.,Grossman, T.H.,Ocain, T.,Clardy, J.
Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.
Structure Fold.Des., 8:25-33, 2000
PubMed: 10673429 (PDB entries with the same primary citation)
DOI: 10.1016/S0969-2126(00)00077-0
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.183601.4%7.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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