2PRL

The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site

Summary for 2PRL

Entry DOI	10.2210/pdb2prl/pdb
Related	1D3G 2PRH 2PRM
Descriptor	Dihydroorotate dehydrogenase, mitochondrial, SULFATE ION, ACETATE ION, ... (8 entities in total)
Functional Keywords	protein inhibitor complex, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion inner membrane ; Single-pass membrane protein : Q02127
Total number of polymer chains	1
Total formula weight	41219.83
Authors	Walse, B.,Dufe, V.T.,Al-Karadaghi, S. (deposition date: 2007-05-04, release date: 2008-05-20, Last modification date: 2023-08-30)
Primary citation	Walse, B.,Dufe, V.T.,Svensson, B.,Fritzson, I.,Dahlberg, L.,Khairoullina, A.,Wellmar, U.,Al-Karadaghi, S. The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites Biochemistry, 47:8929-8936, 2008 Cited by PubMed: 18672895 DOI: 10.1021/bi8003318 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation