2PRL
The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dihydroorotate dehydrogenase, mitochondrial | polymer | 367 | 39856.5 | 1 | UniProt (Q02127) Pfam (PF01180) | Homo sapiens (human) | (Dihydroorotate oxidase; DHOdehase |
| 2 | B (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | C, D (A) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 4 | E (A) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 5 | F (A) | OROTIC ACID | non-polymer | 156.1 | 1 | Chemie (ORO) | |||
| 6 | G (A) | 5-METHOXY-2-[(4-PHENOXYPHENYL)AMINO]BENZOIC ACID | non-polymer | 335.4 | 1 | Chemie (R2C) | |||
| 7 | H (A) | DECYLAMINE-N,N-DIMETHYL-N-OXIDE | non-polymer | 201.3 | 1 | Chemie (DDQ) | |||
| 8 | I (A) | water | water | 18.0 | 231 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39856.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1363.3 | |
| All* | Total formula weight | 41219.8 |
