3I65

Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM1

Summary for 3I65

• Entry DOI: 10.2210/pdb3i65/pdb
• Related: 3I68 3I6R
• Descriptor: Dihydroorotate dehydrogenase homolog, mitochondrial, 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, FLAVIN MONONUCLEOTIDE, ... (6 entities in total)
• Functional Keywords: plasmodium falciparum, dihydroorotate dehydrogenase, triazolopyrimidine, inhibitor, dsm1, fad, flavoprotein, membrane, mitochondrion, mitochondrion inner membrane, oxidoreductase, pyrimidine biosynthesis, transit peptide
• Biological source: Plasmodium falciparum 3D7
• Cellular location: Mitochondrion inner membrane (By similarity); Single-pass membrane protein (Potential): Q08210
• Total number of polymer chains: 1
• Total formula weight: 47771.51

Authors

Deng, X.,Phillips, M.A. (deposition date: 2009-07-06, release date: 2009-07-28, Last modification date: 2023-09-06)

• Primary citation: Deng, X.,Gujjar, R.,El Mazouni, F.,Kaminsky, W.,Malmquist, N.A.,Goldsmith, E.J.,Rathod, P.K.,Phillips, M.A.; Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.; J.Biol.Chem., 284:26999-27009, 2009; PubMed: 19640844; DOI: 10.1074/jbc.M109.028589

Experimental method

X-RAY DIFFRACTION (2 Å)