3I68

Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM2

Summary for 3I68

Entry DOI	10.2210/pdb3i68/pdb
Related	3I65 3I68
Descriptor	Dihydroorotate dehydrogenase homolog, mitochondrial, N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, FLAVIN MONONUCLEOTIDE, ... (5 entities in total)
Functional Keywords	plasmodium falciparum, dihydroorotate dehydrogenase, triazolopyrimidine, inhibitor, dsm2, fad, flavoprotein, membrane, mitochondrion, mitochondrion inner membrane, oxidoreductase, pyrimidine biosynthesis, transit peptide
Biological source	Plasmodium falciparum 3D7
Cellular location	Mitochondrion inner membrane (By similarity); Single-pass membrane protein (Potential): Q08210
Total number of polymer chains	1
Total formula weight	47590.15
Authors	Deng, X.,Phillips, M.A. (deposition date: 2009-07-06, release date: 2009-07-28, Last modification date: 2023-09-06)
Primary citation	Deng, X.,Gujjar, R.,El Mazouni, F.,Kaminsky, W.,Malmquist, N.A.,Goldsmith, E.J.,Rathod, P.K.,Phillips, M.A. Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds. J.Biol.Chem., 284:26999-27009, 2009 Cited by PubMed: 19640844 DOI: 10.1074/jbc.M109.028589 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation