3I68
Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Dihydroorotate dehydrogenase homolog, mitochondrial | polymer | 415 | 46652.3 | 1 | UniProt (Q08210) Pfam (PF01180) In PDB | Plasmodium falciparum 3D7 | DHOdehase, Dihydroorotate oxidase |
| 2 | A | N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine | non-polymer | 325.4 | 1 | Chemie (J4Z) | |||
| 3 | A | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 4 | A | OROTIC ACID | non-polymer | 156.1 | 1 | Chemie (ORO) | |||
| 5 | water | water | 18.0 | 63 | Chemie (HOH) |
Sequence modifications
A: 158 - 569 (UniProt: Q08210)
| PDB | External Database | Details |
|---|---|---|
| Met 125 | - | expression tag |
| Gly 126 | - | expression tag |
| Ser 127 | - | expression tag |
| Ser 128 | - | expression tag |
| His 129 | - | expression tag |
| His 130 | - | expression tag |
| His 131 | - | expression tag |
| His 132 | - | expression tag |
| His 133 | - | expression tag |
| His 134 | - | expression tag |
| Ser 135 | - | expression tag |
| Ser 136 | - | expression tag |
| Gly 137 | - | expression tag |
| Leu 138 | - | expression tag |
| Val 139 | - | expression tag |
| Pro 140 | - | expression tag |
| Arg 141 | - | expression tag |
| Gly 142 | - | expression tag |
| Ser 143 | - | expression tag |
| His 144 | - | expression tag |
| Met 145 | - | expression tag |
| Ala 146 | - | expression tag |
| Ser 147 | - | expression tag |
| Met 148 | - | expression tag |
| Thr 149 | - | expression tag |
| Gly 150 | - | expression tag |
| Gly 151 | - | expression tag |
| Gln 152 | - | expression tag |
| Gln 153 | - | expression tag |
| Gly 154 | - | expression tag |
| Arg 155 | - | expression tag |
| Asp 156 | - | expression tag |
| Pro 157 | - | expression tag |
| - | Ser 384 | deletion |
| - | Thr 385 | deletion |
| - | Tyr 386 | deletion |
| - | Asn 387 | deletion |
| - | Glu 388 | deletion |
| - | Asp 389 | deletion |
| - | Asn 390 | deletion |
| - | Lys 391 | deletion |
| - | Ile 392 | deletion |
| - | Val 393 | deletion |
| - | Glu 394 | deletion |
| - | Lys 395 | deletion |
| - | Lys 396 | deletion |
| - | Asn 397 | deletion |
| - | Asn 398 | deletion |
| - | Phe 399 | deletion |
| - | Asn 400 | deletion |
| - | Lys 401 | deletion |
| - | Asn 402 | deletion |
| - | Asn 403 | deletion |
| - | Ser 404 | deletion |
| - | His 405 | deletion |
| - | Met 406 | deletion |
| - | Met 407 | deletion |
| - | Lys 408 | deletion |
| - | Asp 409 | deletion |
| - | Ala 410 | deletion |
| - | Lys 411 | deletion |
| - | Asp 412 | deletion |
| - | Asn 413 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 46652.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 937.8 | |
| All* | Total formula weight | 47590.2 |
