3KVL

Crystal structure of human dihydroorotate dehydrogenase (DHODH) with amino-benzoic acid inhibitor 715 at 1.85A resolution

Summary for 3KVL

Entry DOI	10.2210/pdb3kvl/pdb
Related	3KVJ 3KVK 3KVM
Descriptor	Dihydroorotate dehydrogenase, mitochondrial, SULFATE ION, FLAVIN MONONUCLEOTIDE, ... (8 entities in total)
Functional Keywords	protein-antiproliferative agent complex, oxidoreductase, flavoprotein, fmn, membrane, mitochondrion, mitochondrion inner membrane, polymorphism, pyrimidine biosynthesis, transit peptide, transmembrane
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion inner membrane ; Single-pass membrane protein : Q02127
Total number of polymer chains	1
Total formula weight	43934.70
Authors	McLean, L.,Zhang, Y. (deposition date: 2009-11-30, release date: 2010-03-02, Last modification date: 2023-09-06)
Primary citation	McLean, L.R.,Zhang, Y.,Degnen, W.,Peppard, J.,Cabel, D.,Zou, C.,Tsay, J.T.,Subramaniam, A.,Vaz, R.J.,Li, Y. Discovery of novel inhibitors for DHODH via virtual screening and X-ray crystallographic structures. Bioorg.Med.Chem.Lett., 20:1981-1984, 2010 Cited by PubMed: 20153645 DOI: 10.1016/j.bmcl.2010.01.115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation