3KVM
Crystal structure of human dihydroorotate dehydrogenase (DHODH) with amino-benzoic acid inhibitor 951 at 2.00A resolution
Summary for 3KVM
Entry DOI | 10.2210/pdb3kvm/pdb |
Related | 3KVJ 3KVK 3KVL |
Descriptor | Dihydroorotate dehydrogenase, mitochondrial, SULFATE ION, FLAVIN MONONUCLEOTIDE, ... (8 entities in total) |
Functional Keywords | protein-antiproliferative agent complex, oxidoreductase, flavoprotein, fmn, membrane, mitochondrion, mitochondrion inner membrane, polymorphism, pyrimidine biosynthesis, transit peptide, transmembrane |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion inner membrane ; Single-pass membrane protein : Q02127 |
Total number of polymer chains | 1 |
Total formula weight | 43962.11 |
Authors | McLean, L.,Zhang, Y. (deposition date: 2009-11-30, release date: 2010-03-02, Last modification date: 2023-09-06) |
Primary citation | McLean, L.R.,Zhang, Y.,Degnen, W.,Peppard, J.,Cabel, D.,Zou, C.,Tsay, J.T.,Subramaniam, A.,Vaz, R.J.,Li, Y. Discovery of novel inhibitors for DHODH via virtual screening and X-ray crystallographic structures. Bioorg.Med.Chem.Lett., 20:1981-1984, 2010 Cited by PubMed: 20153645DOI: 10.1016/j.bmcl.2010.01.115 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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