3O8A

Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with novel Inhibitor Genz667348

Summary for 3O8A

• Entry DOI: 10.2210/pdb3o8a/pdb
• Descriptor: Dihydroorotate dehydrogenase homolog, mitochondrial, N-cyclopropyl-5-[2-methyl-5-(trifluoromethoxy)-1H-benzimidazol-1-yl]thiophene-2-carboxamide, FLAVIN MONONUCLEOTIDE, ... (6 entities in total)
• Functional Keywords: alpha beta fold, dihydroorotate dehydrogenase, oxidoreductase, pyrimidine biosynthesis, genz667348, fad, flavoprotein, mitochondrion inner membrane
• Biological source: Plasmodium falciparum; More
• Cellular location: Mitochondrion inner membrane ; Single-pass membrane protein : Q08210
• Total number of polymer chains: 1
• Total formula weight: 47875.56

Authors

Deng, X.,Booker, M.L.,Phillips, M.A. (deposition date: 2010-08-02, release date: 2010-08-18, Last modification date: 2024-02-21)

• Primary citation: Booker, M.L.,Bastos, C.M.,Kramer, M.L.,Barker, R.H.,Skerlj, R.,Sidhu, A.B.,Deng, X.,Celatka, C.,Cortese, J.F.,Guerrero Bravo, J.E.,Crespo Llado, K.N.,Serrano, A.E.,Angulo-Barturen, I.,Jimenez-Diaz, M.B.,Viera, S.,Garuti, H.,Wittlin, S.,Papastogiannidis, P.,Lin, J.W.,Janse, C.J.,Khan, S.M.,Duraisingh, M.,Coleman, B.,Goldsmith, E.J.,Phillips, M.A.,Munoz, B.,Wirth, D.F.,Klinger, J.D.,Wiegand, R.,Sybertz, E.; Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model.; J.Biol.Chem., 285:33054-33064, 2010; PubMed: 20702404; DOI: 10.1074/jbc.M110.162081

Experimental method

X-RAY DIFFRACTION (2.3 Å)