3O8A
Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with novel Inhibitor Genz667348
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dihydroorotate dehydrogenase homolog, mitochondrial | polymer | 415 | 46652.3 | 1 | UniProt (Q08210) Pfam (PF01180) In PDB | Plasmodium falciparum | DHOdehase, Dihydroorotate oxidase |
2 | A | N-cyclopropyl-5-[2-methyl-5-(trifluoromethoxy)-1H-benzimidazol-1-yl]thiophene-2-carboxamide | non-polymer | 381.4 | 1 | Chemie (O8A) | |||
3 | A | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
4 | A | OROTIC ACID | non-polymer | 156.1 | 1 | Chemie (ORO) | |||
5 | A | LAURYL DIMETHYLAMINE-N-OXIDE | non-polymer | 229.4 | 1 | Chemie (LDA) | |||
6 | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
A: 158 - 383 (UniProt: Q08210)
A: 414 - 569 (UniProt: Q08210)
PDB | External Database | Details |
---|---|---|
Met 125 | - | expression tag |
Gly 126 | - | expression tag |
Ser 127 | - | expression tag |
Ser 128 | - | expression tag |
His 129 | - | expression tag |
His 130 | - | expression tag |
His 131 | - | expression tag |
His 132 | - | expression tag |
His 133 | - | expression tag |
His 134 | - | expression tag |
Ser 135 | - | expression tag |
Ser 136 | - | expression tag |
Gly 137 | - | expression tag |
Leu 138 | - | expression tag |
Val 139 | - | expression tag |
Pro 140 | - | expression tag |
Arg 141 | - | expression tag |
Gly 142 | - | expression tag |
Ser 143 | - | expression tag |
His 144 | - | expression tag |
Met 145 | - | expression tag |
Ala 146 | - | expression tag |
Ser 147 | - | expression tag |
Met 148 | - | expression tag |
Thr 149 | - | expression tag |
Gly 150 | - | expression tag |
Gly 151 | - | expression tag |
Gln 152 | - | expression tag |
Gln 153 | - | expression tag |
Gly 154 | - | expression tag |
Arg 155 | - | expression tag |
Asp 156 | - | expression tag |
Pro 157 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 46652.3 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1223.2 | |
All* | Total formula weight | 47875.6 |