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3G0X

Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 5

Summary for 3G0X
Entry DOI10.2210/pdb3g0x/pdb
Related3F1Q 3FJ6 3FJL 3G0U
DescriptorDihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (6 entities in total)
Functional Keywordsbeta barrel, tim barrel, fad, flavoprotein, membrane, mitochondrion, mitochondrion inner membrane, oxidoreductase, polymorphism, pyrimidine biosynthesis, transit peptide
Biological sourceHomo sapiens (human)
Cellular locationMitochondrion inner membrane; Single-pass membrane protein: Q02127
Total number of polymer chains1
Total formula weight40869.38
Authors
Davies, M.,Heikkila, T.,McConkey, G.A.,Fishwick, C.W.G.,Parsons, M.R.,Johnson, A.P. (deposition date: 2009-01-29, release date: 2009-06-09, Last modification date: 2024-03-20)
Primary citationDavies, M.,Heikkila, T.,McConkey, G.A.,Fishwick, C.W.G.,Parsons, M.R.,Johnson, A.P.
Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases
J.Med.Chem., 52:2683-2693, 2009
Cited by
PubMed: 19351152
DOI: 10.1021/jm800963t
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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