3FJL

Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 3

Summary for 3FJL

Entry DOI	10.2210/pdb3fjl/pdb
Related	3F1Q 3FJ6
Descriptor	Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (7 entities in total)
Functional Keywords	alpha-beta barrel, tim barrel, fad, flavoprotein, membrane, mitochondrion, mitochondrion inner membrane, oxidoreductase, polymorphism, pyrimidine biosynthesis, transit peptide
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion inner membrane; Single-pass membrane protein: Q02127
Total number of polymer chains	1
Total formula weight	41007.50
Authors	Heikkila, T. (deposition date: 2008-12-14, release date: 2009-06-09, Last modification date: 2024-03-20)
Primary citation	Davies, M.,Heikkila, T.,McConkey, G.A.,Fishwick, C.W.G.,Parsons, M.R.,Johnson, A.P. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52:2683-2693, 2009 Cited by PubMed: 19351152 DOI: 10.1021/jm800963t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation