5NKZ
 
 | | Crystal structure of H. polymorpha ubiquitin conjugating enzyme Pex4p in complex with soluble domain of Pex22p | | Descriptor: | Peroxin 22, Ubiquitin-conjugating enzyme E2-21 kDa | | Authors: | Danda, N, Lunev, S, Ali, A, Groves, M.R, Williams, C. | | Deposit date: | 2017-04-03 | | Release date: | 2018-01-24 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Structural insights into K48-linked ubiquitin chain formation by the Pex4p-Pex22p complex.
Biochem. Biophys. Res. Commun., 496, 2018
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7K5J
 | | Structure of an E1-E2-ubiquitin thioester mimetic | | Descriptor: | ADENOSINE MONOPHOSPHATE, Ubiquitin, Ubiquitin-activating enzyme E1 1, ... | | Authors: | Yuan, L, Lv, Z, Olsen, S.K. | | Deposit date: | 2020-09-16 | | Release date: | 2021-04-28 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.42 Å) | | Cite: | Crystal structures of an E1-E2-ubiquitin thioester mimetic reveal molecular mechanisms of transthioesterification.
Nat Commun, 12, 2021
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3K9O
 | | The crystal structure of E2-25K and UBB+1 complex | | Descriptor: | Ubiquitin, Ubiquitin-conjugating enzyme E2 K | | Authors: | Kang, G.B, Ko, S, Song, S.M, Lee, W, Eom, S.H. | | Deposit date: | 2009-10-16 | | Release date: | 2010-09-08 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural Basis of E2-25K/UBB+1 Interaction for Neurotoxicity of Alzheimer Disease by Proteasome Inhibition
To be Published
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3PTF
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5MNJ
 | | Structure of MDM2-MDMX-UbcH5B-ubiquitin complex | | Descriptor: | E3 ubiquitin-protein ligase Mdm2, Polyubiquitin-B, Protein Mdm4, ... | | Authors: | Klejnot, M, Huang, D.T. | | Deposit date: | 2016-12-13 | | Release date: | 2017-05-31 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity.
Nat. Struct. Mol. Biol., 24, 2017
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3K9P
 | | The crystal structure of E2-25K and ubiquitin complex | | Descriptor: | Ubiquitin, Ubiquitin-conjugating enzyme E2 K | | Authors: | Kang, G.B, Ko, S, Song, S.M, Lee, W, Eom, S.H. | | Deposit date: | 2009-10-16 | | Release date: | 2010-09-08 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity
J.Biol.Chem., 285, 2010
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3JW0
 | | E2~Ubiquitin-HECT | | Descriptor: | E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2 | | Authors: | Kamadurai, H.B, Schulman, B.A. | | Deposit date: | 2009-09-17 | | Release date: | 2010-01-12 | | Last modified: | 2021-10-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex.
Mol.Cell, 36, 2009
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3JVZ
 | | E2~Ubiquitin-HECT | | Descriptor: | E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2 | | Authors: | Souphron, J, Kamadurai, H.B, Schulman, B.A. | | Deposit date: | 2009-09-17 | | Release date: | 2010-01-12 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex.
Mol.Cell, 36, 2009
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7KZR
 | | Structure of the human Fanconi Anaemia Core-UBE2T-ID complex | | Descriptor: | E3 ubiquitin-protein ligase FANCL, Fanconi anemia core complex-associated protein 100, Fanconi anemia core complex-associated protein 20, ... | | Authors: | Wang, S.L, Pavletich, N.P. | | Deposit date: | 2020-12-10 | | Release date: | 2021-03-10 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structure of the FA core ubiquitin ligase closing the ID clamp on DNA.
Nat.Struct.Mol.Biol., 28, 2021
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7KZV
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7KZT
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7KZS
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8IVQ
 | | Cryo-EM structure of mouse BIRC6, Global map | | Descriptor: | Isoform 2 of Baculoviral IAP repeat-containing protein 6 | | Authors: | Liu, S, Jiang, T, Bu, F, Zhao, J, Wang, G, Li, N, Gao, N, Qiu, X. | | Deposit date: | 2023-03-28 | | Release date: | 2024-01-24 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Molecular mechanisms underlying the BIRC6-mediated regulation of apoptosis and autophagy.
Nat Commun, 15, 2024
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4JQU
 | | Crystal structure of Ubc7p in complex with the U7BR of Cue1p | | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Coupling of ubiquitin conjugation to ER degradation protein 1, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Liang, Y.-H, Metzger, M.B, Weissman, A.M, Ji, X. | | Deposit date: | 2013-03-20 | | Release date: | 2013-05-29 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | A Structurally Unique E2-Binding Domain Activates Ubiquitination by the ERAD E2, Ubc7p, through Multiple Mechanisms.
Mol.Cell, 50, 2013
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3L1Z
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4LDT
 | | The structure of h/ceOTUB1-ubiquitin aldehyde-UBCH5B~Ub | | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, Ubiquitin, ... | | Authors: | Wiener, R, DiBello, A.T, Lombardi, P.M, Guzzo, C.M, Zhang, X, Matunis, M.J, Wolberger, C. | | Deposit date: | 2013-06-25 | | Release date: | 2013-08-14 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (1.901 Å) | | Cite: | E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1.
Nat.Struct.Mol.Biol., 20, 2013
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3OJ4
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3RCZ
 | | Rad60 SLD2 Ubc9 Complex | | Descriptor: | DNA repair protein rad60, SUMO-conjugating enzyme ubc9 | | Authors: | Perry, J.J.P, Arvai, A.S, Tainer, J.A. | | Deposit date: | 2011-03-31 | | Release date: | 2011-04-27 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes.
Mol.Cell.Biol., 31, 2011
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4LAD
 | | Crystal Structure of the Ube2g2:RING-G2BR complex | | Descriptor: | E3 ubiquitin-protein ligase AMFR, OXALATE ION, Ubiquitin-conjugating enzyme E2 G2, ... | | Authors: | Liang, Y.-H, Li, J, Das, R, Byrd, R.A, Ji, X. | | Deposit date: | 2013-06-19 | | Release date: | 2013-08-28 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine.
Embo J., 32, 2013
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3RPG
 | | Bmi1/Ring1b-UbcH5c complex structure | | Descriptor: | E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1, Ubiquitin-conjugating enzyme E2 D3, ... | | Authors: | Bentley, M.L, Dong, K.C, Cochran, A.G. | | Deposit date: | 2011-04-26 | | Release date: | 2011-08-17 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.6485 Å) | | Cite: | Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex.
Embo J., 30, 2011
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5ULK
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4W5V
 | | Crystal structure of Human SUMO E2-conjugating enzyme (Ubc9) in complex with E1-activating enzyme (Uba2) ubiquitin fold domain (Ufd) | | Descriptor: | FORMIC ACID, GLYCEROL, POTASSIUM ION, ... | | Authors: | Boucher, L.E, Reiter, K.H, Matunis, M.J, Bosch, J. | | Deposit date: | 2014-08-19 | | Release date: | 2015-09-09 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of human SUMO complex
To Be Published
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4YII
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4V3K
 | | RNF38-UbcH5B-UB complex | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, E3 UBIQUITIN-PROTEIN LIGASE RNF38, ... | | Authors: | Buetow, L, Gabrielsen, M, Anthony, N.G, Dou, H, Patel, A, Aitkenhead, H, Sibbet, G.J, Smith, B.O, Huang, D.T. | | Deposit date: | 2014-10-20 | | Release date: | 2015-04-08 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin.
Mol.Cell, 58, 2015
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6TTU
 | | Ubiquitin Ligation to substrate by a cullin-RING E3 ligase at 3.7A resolution: NEDD8-CUL1-RBX1 N98R-SKP1-monomeric b-TRCP1dD-IkBa-UB~UBE2D2 | | Descriptor: | CYS-LYS-LYS-ALA-ARG-HIS-ASP-SEP-GLY, Cullin-1, E3 ubiquitin-protein ligase RBX1, ... | | Authors: | Baek, K, Prabu, J.R, Schulman, B.A. | | Deposit date: | 2019-12-30 | | Release date: | 2020-02-12 | | Last modified: | 2020-03-04 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly.
Nature, 578, 2020
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