6M2C

Distinct mechanism of MUL1-RING domain simultaneously recruiting E2 enzyme and the substrate p53-TAD domain

Summary for 6M2C

Entry DOI	10.2210/pdb6m2c/pdb
Descriptor	Ubiquitin-conjugating enzyme E2 D2, Mitochondrial ubiquitin ligase activator of NFKB 1, ZINC ION, ... (4 entities in total)
Functional Keywords	mul1-ring, ube2d2, structural protein, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	8
Total formula weight	92550.10
Authors	Lee, S.O.,Ryu, K.S.,Chi, S.-W. (deposition date: 2020-02-27, release date: 2021-04-07, Last modification date: 2023-11-29)
Primary citation	Lee, M.S.,Lee, S.O.,Choi, J.,Ryu, M.,Lee, M.K.,Kim, J.H.,Hwang, E.,Lee, C.K.,Chi, S.W.,Ryu, K.S. MUL1-RING recruits the substrate, p53-TAD as a complex with UBE2D2-UB conjugate. Febs J., 2022 Cited by PubMed: 35048531 DOI: 10.1111/febs.16360 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.702 Å)

Structure validation