7D8X
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![BU of 7d8x by Molmil](/molmil-images/mine/7d8x) | CryoEM structure of human gamma-secretase in complex with E2012 and L685458 | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]piperidin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yang, G, Zhou, R, Guo, X, Lei, J, Yan, C, Shi, Y. | Deposit date: | 2020-10-11 | Release date: | 2021-01-27 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural basis of gamma-secretase inhibition and modulation by small molecule drugs. Cell, 184, 2021
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2E45
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6LQG
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![BU of 6lqg by Molmil](/molmil-images/mine/6lqg) | Human gamma-secretase in complex with small molecule Avagacestat | Descriptor: | (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoranyl-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-tris(fluoranyl)pentanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yang, G, Zhou, R, Guo, X, Lei, J, Shi, Y. | Deposit date: | 2020-01-13 | Release date: | 2021-01-27 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of gamma-secretase inhibition and modulation by small molecule drugs. Cell, 184, 2021
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6LR4
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![BU of 6lr4 by Molmil](/molmil-images/mine/6lr4) | Molecular basis for inhibition of human gamma-secretase by small molecule | Descriptor: | (2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yang, G, Zhou, R, Guo, X, Lei, J, Shi, Y. | Deposit date: | 2020-01-15 | Release date: | 2021-01-27 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of gamma-secretase inhibition and modulation by small molecule drugs. Cell, 184, 2021
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8C3H
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7C9I
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![BU of 7c9i by Molmil](/molmil-images/mine/7c9i) | Human gamma-secretase in complex with small molecule L-685,458 | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yang, G, Zhou, R, Guo, X, Lei, J, Yan, C, Shi, Y. | Deposit date: | 2020-06-05 | Release date: | 2021-01-27 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of gamma-secretase inhibition and modulation by small molecule drugs. Cell, 184, 2021
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5FN4
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![BU of 5fn4 by Molmil](/molmil-images/mine/5fn4) | Cryo-EM structure of gamma secretase in class 2 of the apo- state ensemble | Descriptor: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | Authors: | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | Deposit date: | 2015-11-10 | Release date: | 2015-12-16 | Last modified: | 2019-09-11 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Sampling the conformational space of the catalytic subunit of human gamma-secretase. Elife, 4, 2015
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5FN3
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![BU of 5fn3 by Molmil](/molmil-images/mine/5fn3) | Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble | Descriptor: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | Authors: | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | Deposit date: | 2015-11-10 | Release date: | 2015-12-16 | Last modified: | 2019-09-11 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Sampling the conformational space of the catalytic subunit of human gamma-secretase. Elife, 4, 2015
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5FN2
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![BU of 5fn2 by Molmil](/molmil-images/mine/5fn2) | Cryo-EM structure of gamma secretase in complex with a drug DAPT | Descriptor: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | Authors: | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | Deposit date: | 2015-11-10 | Release date: | 2015-12-16 | Last modified: | 2019-09-04 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Sampling the conformational space of the catalytic subunit of human gamma-secretase. Elife, 4, 2015
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5FN5
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![BU of 5fn5 by Molmil](/molmil-images/mine/5fn5) | Cryo-EM structure of gamma secretase in class 3 of the apo- state ensemble | Descriptor: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | Authors: | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | Deposit date: | 2015-11-10 | Release date: | 2015-12-16 | Last modified: | 2019-09-11 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Sampling the conformational space of the catalytic subunit of human gamma-secretase. Elife, 4, 2015
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6IDF
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![BU of 6idf by Molmil](/molmil-images/mine/6idf) | Cryo-EM structure of gamma secretase in complex with a Notch fragment | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yang, G, Zhou, R, Zhou, Q, Guo, X, Yan, C, Ke, M, Lei, J, Shi, Y. | Deposit date: | 2018-09-09 | Release date: | 2018-12-26 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural basis of Notch recognition by human gamma-secretase Nature, 565, 2019
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6VU4
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![BU of 6vu4 by Molmil](/molmil-images/mine/6vu4) | Structure of a beta-hairpin peptide mimic derived from Abeta 14-36 | Descriptor: | Beta-hairpin Amyloid-beta precursor peptide mimic, CHLORIDE ION, IODIDE ION | Authors: | Wierzbicki, M, Kreutzer, A, Samdin, T, Nowick, J.S. | Deposit date: | 2020-02-14 | Release date: | 2020-06-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.077 Å) | Cite: | Effects of N-Terminal Residues on the Assembly of Constrained beta-Hairpin Peptides Derived from A beta. J.Am.Chem.Soc., 142, 2020
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8IM7
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![BU of 8im7 by Molmil](/molmil-images/mine/8im7) | Human gamma-secretase treated with ganglioside GM1 | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhou, R, Yang, G, Shi, Y. | Deposit date: | 2023-03-06 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Preferential Regulation of Gamma-Secretase-Mediated Cleavage of APP by Ganglioside GM1 Reveals a Potential Therapeutic Target for Alzheimer's Disease. Adv Sci, 10, 2023
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8K8E
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![BU of 8k8e by Molmil](/molmil-images/mine/8k8e) | Human gamma-secretase in complex with a substrate mimetic | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Shi, Y.G, Zhou, R, Wolfe, M.S. | Deposit date: | 2023-07-29 | Release date: | 2024-01-31 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Familial Alzheimer mutations stabilize synaptotoxic gamma-secretase-substrate complexes. Cell Rep, 43, 2024
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6F25
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![BU of 6f25 by Molmil](/molmil-images/mine/6f25) | Crystal structure of human acetylcholinesterase in complex with C35. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Dias, J, Nachon, F. | Deposit date: | 2017-11-23 | Release date: | 2018-12-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.05199647 Å) | Cite: | New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease. Neuropharmacology, 155, 2019
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7DWV
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![BU of 7dwv by Molmil](/molmil-images/mine/7dwv) | Cryo-EM structure of amyloid fibril formed by familial prion disease-related mutation E196K | Descriptor: | Major prion protein | Authors: | Wang, L.Q, Zhao, K, Yuan, H.Y, Li, X.N, Dang, H.B, Ma, Y.Y, Wang, Q, Wang, C, Sun, Y.P, Chen, J, Li, D, Zhang, D.L, Yin, P, Liu, C, Liang, Y. | Deposit date: | 2021-01-18 | Release date: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Genetic prion disease-related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM. Sci Adv, 7, 2021
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4B1D
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![BU of 4b1d by Molmil](/molmil-images/mine/4b1d) | New Aminoimidazoles as BACE-1 Inhibitors: From Rational Design to Ab- lowering in Brain | Descriptor: | (2S)-2-(4-methoxy-3,5-dimethylphenyl)-5-methyl-2-(3-pyrimidin-5-ylphenyl)-2H-imidazol-4-amine, ACETATE ION, BETA-SECRETASE 1 | Authors: | Rahm, F, Blid, J, Ginman, T, Karlstrom, S, Kihlstrom, J, Kolmodin, K, Lindstrom, J, von Berg, S, von Kieseritzky, F, Slivo, C, Swahn, B, Viklund, J, Olsson, L, Johansson, P, Eketjall, S, Falting, J, Jeppsson, F, Stromberg, K, Janson, J, Gravenfors, Y. | Deposit date: | 2012-07-10 | Release date: | 2012-10-10 | Last modified: | 2018-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | New aminoimidazoles as beta-secretase (BACE-1) inhibitors showing amyloid-beta (A beta ) lowering in brain. J. Med. Chem., 55, 2012
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4B1E
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![BU of 4b1e by Molmil](/molmil-images/mine/4b1e) | New Aminoimidazoles as BACE-1 Inhibitors: From Rational Design to Ab- lowering in Brain | Descriptor: | (2R)-2-methyl-5-phenyl-2-(3-pyridin-3-ylphenyl)-2,3-dihydro-1H-imidazol-4-amine, BETA-SECRETASE 1 | Authors: | Rahm, F, Blid, J, Ginman, T, Karlstrom, S, Kihlstrom, J, Kolmodin, K, Lindstrom, J, von Berg, S, von Kieseritzky, F, Slivo, C, Swahn, B, Viklund, J, Olsson, L, Johansson, P, Eketjall, S, Falting, J, Jeppsson, F, Stromberg, K, Janson, J, Gravenfors, Y. | Deposit date: | 2012-07-10 | Release date: | 2012-10-10 | Last modified: | 2018-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | New aminoimidazoles as beta-secretase (BACE-1) inhibitors showing amyloid-beta (A beta ) lowering in brain. J. Med. Chem., 55, 2012
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4B1C
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![BU of 4b1c by Molmil](/molmil-images/mine/4b1c) | New Aminoimidazoles as BACE-1 Inhibitors: From Rational Design to Ab- lowering in Brain | Descriptor: | (2R)-2-cyclopropyl-5-methyl-2-[3-(5-prop-1-yn-1-ylpyridin-3-yl)phenyl]-2H-imidazol-4-amine, BETA-SECRETASE 1, DIMETHYL SULFOXIDE | Authors: | Rahm, F, Blid, J, Ginman, T, Karlstrom, S, Kihlstrom, J, Kolmodin, K, Lindstrom, J, von Berg, S, von Kieseritzky, F, Slivo, C, Swahn, B, Viklund, J, Olsson, L, Johansson, P, Eketjall, S, Falting, J, Jeppsson, F, Stromberg, K, Janson, J, Gravenfors, Y. | Deposit date: | 2012-07-10 | Release date: | 2012-10-10 | Last modified: | 2018-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | New aminoimidazoles as beta-secretase (BACE-1) inhibitors showing amyloid-beta (A beta ) lowering in brain. J. Med. Chem., 55, 2012
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2DYQ
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![BU of 2dyq by Molmil](/molmil-images/mine/2dyq) | Crystal Structure of the C-terminal Phophotyrosine Interaction Domain of Human APBB3 | Descriptor: | Amyloid beta A4 precursor protein-binding family B member 3 | Authors: | Nishino, A, Saijo, S, Kishishita, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-09-16 | Release date: | 2007-09-18 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal Structure of the C-terminal Phophotyrosine Interaction Domain of Human APBB3 To be Published
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1XN2
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![BU of 1xn2 by Molmil](/molmil-images/mine/1xn2) | New substrate binding pockets for beta-secretase. | Descriptor: | Beta-secretase 1, OM03-4 | Authors: | Turner III, R.T, Hong, L, Koelsch, G, Ghosh, A.K, Tang, J. | Deposit date: | 2004-10-04 | Release date: | 2005-03-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase). Biochemistry, 44, 2005
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1XN3
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![BU of 1xn3 by Molmil](/molmil-images/mine/1xn3) | Crystal structure of Beta-secretase bound to a long inhibitor with additional upstream residues. | Descriptor: | Beta-secretase 1, Peptidic inhibitor | Authors: | Turner III, R.T, Hong, L, Koelsch, G, Ghosh, A.K, Tang, J. | Deposit date: | 2004-10-04 | Release date: | 2005-03-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase). Biochemistry, 44, 2005
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2GD3
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![BU of 2gd3 by Molmil](/molmil-images/mine/2gd3) | NMR structure of S14G-humanin in 30% TFE solution | Descriptor: | Humanin | Authors: | Benaki, D, Zikos, C, Evangelou, A, Livaniou, E, Vlassi, M, Mikros, E, Pelecanou, M. | Deposit date: | 2006-03-15 | Release date: | 2006-09-19 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease. Biochem.Biophys.Res.Commun., 349, 2006
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2HO2
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![BU of 2ho2 by Molmil](/molmil-images/mine/2ho2) | |
2IDH
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![BU of 2idh by Molmil](/molmil-images/mine/2idh) | |