6F25

Crystal structure of human acetylcholinesterase in complex with C35.

Summary for 6F25

Entry DOI	10.2210/pdb6f25/pdb
Descriptor	Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	acetylcholinesterase, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	123416.54
Authors	Dias, J.,Nachon, F. (deposition date: 2017-11-23, release date: 2018-12-12, Last modification date: 2024-01-17)
Primary citation	Zueva, I.,Dias, J.,Lushchekina, S.,Semenov, V.,Mukhamedyarov, M.,Pashirova, T.,Babaev, V.,Nachon, F.,Petrova, N.,Nurullin, L.,Zakharova, L.,Ilyin, V.,Masson, P.,Petrov, K. New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease. Neuropharmacology, 155:131-141, 2019 Cited by PubMed: 31132435 DOI: 10.1016/j.neuropharm.2019.05.025 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.05199647812 Å)

Structure validation