7DWV

Cryo-EM structure of amyloid fibril formed by familial prion disease-related mutation E196K

Summary for 7DWV

Entry DOI	10.2210/pdb7dwv/pdb
EMDB information	30887
Descriptor	Major prion protein (1 entity in total)
Functional Keywords	amyloid fibril, protein fibril
Biological source	Homo sapiens (Human)
Total number of polymer chains	6
Total formula weight	137978.53
Authors	Wang, L.Q.,Zhao, K.,Yuan, H.Y.,Li, X.N.,Dang, H.B.,Ma, Y.Y.,Wang, Q.,Wang, C.,Sun, Y.P.,Chen, J.,Li, D.,Zhang, D.L.,Yin, P.,Liu, C.,Liang, Y. (deposition date: 2021-01-18, release date: 2021-10-13)
Primary citation	Wang, L.Q.,Zhao, K.,Yuan, H.Y.,Li, X.N.,Dang, H.B.,Ma, Y.,Wang, Q.,Wang, C.,Sun, Y.,Chen, J.,Li, D.,Zhang, D.,Yin, P.,Liu, C.,Liang, Y. Genetic prion disease-related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM. Sci Adv, 7:eabg9676-eabg9676, 2021 Cited by PubMed: 34516876 DOI: 10.1126/sciadv.abg9676 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.07 Å)

Structure validation