7DWV

Cryo-EM structure of amyloid fibril formed by familial prion disease-related mutation E196K

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001540	molecular_function	amyloid-beta binding
A	0001933	biological_process	negative regulation of protein phosphorylation
A	0002020	molecular_function	protease binding
A	0005507	molecular_function	copper ion binding
A	0005515	molecular_function	protein binding
A	0005521	molecular_function	lamin binding
A	0005539	molecular_function	glycosaminoglycan binding
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006878	biological_process	intracellular copper ion homeostasis
A	0006979	biological_process	response to oxidative stress
A	0007611	biological_process	learning or memory
A	0007616	biological_process	long-term memory
A	0008017	molecular_function	microtubule binding
A	0009897	cellular_component	external side of plasma membrane
A	0009986	cellular_component	cell surface
A	0010955	biological_process	negative regulation of protein processing
A	0014069	cellular_component	postsynaptic density
A	0015631	molecular_function	tubulin binding
A	0016020	cellular_component	membrane
A	0016234	cellular_component	inclusion body
A	0019828	molecular_function	aspartic-type endopeptidase inhibitor activity
A	0019898	cellular_component	extrinsic component of membrane
A	0030425	cellular_component	dendrite
A	0031648	biological_process	protein destabilization
A	0031802	molecular_function	type 5 metabotropic glutamate receptor binding
A	0031805	molecular_function	type 8 metabotropic glutamate receptor binding
A	0031965	cellular_component	nuclear membrane
A	0032147	biological_process	activation of protein kinase activity
A	0032689	biological_process	negative regulation of type II interferon production
A	0032700	biological_process	negative regulation of interleukin-17 production
A	0032703	biological_process	negative regulation of interleukin-2 production
A	0032880	biological_process	regulation of protein localization
A	0038023	molecular_function	signaling receptor activity
A	0042802	molecular_function	identical protein binding
A	0043008	molecular_function	ATP-dependent protein binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0043086	biological_process	negative regulation of catalytic activity
A	0043195	cellular_component	terminal bouton
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0043433	biological_process	negative regulation of DNA-binding transcription factor activity
A	0043525	biological_process	positive regulation of neuron apoptotic process
A	0044325	molecular_function	transmembrane transporter binding
A	0044877	molecular_function	protein-containing complex binding
A	0045121	cellular_component	membrane raft
A	0046007	biological_process	negative regulation of activated T cell proliferation
A	0046686	biological_process	response to cadmium ion
A	0046688	biological_process	response to copper ion
A	0046872	molecular_function	metal ion binding
A	0050730	biological_process	regulation of peptidyl-tyrosine phosphorylation
A	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
A	0050850	biological_process	positive regulation of calcium-mediated signaling
A	0050860	biological_process	negative regulation of T cell receptor signaling pathway
A	0051087	molecular_function	protein-folding chaperone binding
A	0051260	biological_process	protein homooligomerization
A	0051726	biological_process	regulation of cell cycle
A	0060090	molecular_function	molecular adaptor activity
A	0070062	cellular_component	extracellular exosome
A	0070885	biological_process	negative regulation of calcineurin-NFAT signaling cascade
A	0071280	biological_process	cellular response to copper ion
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	0090314	biological_process	positive regulation of protein targeting to membrane
A	0097062	biological_process	dendritic spine maintenance
A	0098552	cellular_component	side of membrane
A	0098794	cellular_component	postsynapse
A	0140677	molecular_function	molecular function activator activity
A	0140693	molecular_function	molecular condensate scaffold activity
A	1900272	biological_process	negative regulation of long-term synaptic potentiation
A	1900449	biological_process	regulation of glutamate receptor signaling pathway
A	1900451	biological_process	positive regulation of glutamate receptor signaling pathway
A	1901379	biological_process	regulation of potassium ion transmembrane transport
A	1902430	biological_process	negative regulation of amyloid-beta formation
A	1902951	biological_process	negative regulation of dendritic spine maintenance
A	1902992	biological_process	negative regulation of amyloid precursor protein catabolic process
A	1903078	biological_process	positive regulation of protein localization to plasma membrane
A	1903135	molecular_function	cupric ion binding
A	1903136	molecular_function	cuprous ion binding
A	1904645	biological_process	response to amyloid-beta
A	1904646	biological_process	cellular response to amyloid-beta
A	1905664	biological_process	regulation of calcium ion import across plasma membrane
A	1990535	biological_process	neuron projection maintenance
B	0001540	molecular_function	amyloid-beta binding
B	0001933	biological_process	negative regulation of protein phosphorylation
B	0002020	molecular_function	protease binding
B	0005507	molecular_function	copper ion binding
B	0005515	molecular_function	protein binding
B	0005521	molecular_function	lamin binding
B	0005539	molecular_function	glycosaminoglycan binding
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006878	biological_process	intracellular copper ion homeostasis
B	0006979	biological_process	response to oxidative stress
B	0007611	biological_process	learning or memory
B	0007616	biological_process	long-term memory
B	0008017	molecular_function	microtubule binding
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010955	biological_process	negative regulation of protein processing
B	0014069	cellular_component	postsynaptic density
B	0015631	molecular_function	tubulin binding
B	0016020	cellular_component	membrane
B	0016234	cellular_component	inclusion body
B	0019828	molecular_function	aspartic-type endopeptidase inhibitor activity
B	0019898	cellular_component	extrinsic component of membrane
B	0030425	cellular_component	dendrite
B	0031648	biological_process	protein destabilization
B	0031802	molecular_function	type 5 metabotropic glutamate receptor binding
B	0031805	molecular_function	type 8 metabotropic glutamate receptor binding
B	0031965	cellular_component	nuclear membrane
B	0032147	biological_process	activation of protein kinase activity
B	0032689	biological_process	negative regulation of type II interferon production
B	0032700	biological_process	negative regulation of interleukin-17 production
B	0032703	biological_process	negative regulation of interleukin-2 production
B	0032880	biological_process	regulation of protein localization
B	0038023	molecular_function	signaling receptor activity
B	0042802	molecular_function	identical protein binding
B	0043008	molecular_function	ATP-dependent protein binding
B	0043066	biological_process	negative regulation of apoptotic process
B	0043086	biological_process	negative regulation of catalytic activity
B	0043195	cellular_component	terminal bouton
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0043433	biological_process	negative regulation of DNA-binding transcription factor activity
B	0043525	biological_process	positive regulation of neuron apoptotic process
B	0044325	molecular_function	transmembrane transporter binding
B	0044877	molecular_function	protein-containing complex binding
B	0045121	cellular_component	membrane raft
B	0046007	biological_process	negative regulation of activated T cell proliferation
B	0046686	biological_process	response to cadmium ion
B	0046688	biological_process	response to copper ion
B	0046872	molecular_function	metal ion binding
B	0050730	biological_process	regulation of peptidyl-tyrosine phosphorylation
B	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
B	0050850	biological_process	positive regulation of calcium-mediated signaling
B	0050860	biological_process	negative regulation of T cell receptor signaling pathway
B	0051087	molecular_function	protein-folding chaperone binding
B	0051260	biological_process	protein homooligomerization
B	0051726	biological_process	regulation of cell cycle
B	0060090	molecular_function	molecular adaptor activity
B	0070062	cellular_component	extracellular exosome
B	0070885	biological_process	negative regulation of calcineurin-NFAT signaling cascade
B	0071280	biological_process	cellular response to copper ion
B	0071466	biological_process	cellular response to xenobiotic stimulus
B	0090314	biological_process	positive regulation of protein targeting to membrane
B	0097062	biological_process	dendritic spine maintenance
B	0098552	cellular_component	side of membrane
B	0098794	cellular_component	postsynapse
B	0140677	molecular_function	molecular function activator activity
B	0140693	molecular_function	molecular condensate scaffold activity
B	1900272	biological_process	negative regulation of long-term synaptic potentiation
B	1900449	biological_process	regulation of glutamate receptor signaling pathway
B	1900451	biological_process	positive regulation of glutamate receptor signaling pathway
B	1901379	biological_process	regulation of potassium ion transmembrane transport
B	1902430	biological_process	negative regulation of amyloid-beta formation
B	1902951	biological_process	negative regulation of dendritic spine maintenance
B	1902992	biological_process	negative regulation of amyloid precursor protein catabolic process
B	1903078	biological_process	positive regulation of protein localization to plasma membrane
B	1903135	molecular_function	cupric ion binding
B	1903136	molecular_function	cuprous ion binding
B	1904645	biological_process	response to amyloid-beta
B	1904646	biological_process	cellular response to amyloid-beta
B	1905664	biological_process	regulation of calcium ion import across plasma membrane
B	1990535	biological_process	neuron projection maintenance
C	0001540	molecular_function	amyloid-beta binding
C	0001933	biological_process	negative regulation of protein phosphorylation
C	0002020	molecular_function	protease binding
C	0005507	molecular_function	copper ion binding
C	0005515	molecular_function	protein binding
C	0005521	molecular_function	lamin binding
C	0005539	molecular_function	glycosaminoglycan binding
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006878	biological_process	intracellular copper ion homeostasis
C	0006979	biological_process	response to oxidative stress
C	0007611	biological_process	learning or memory
C	0007616	biological_process	long-term memory
C	0008017	molecular_function	microtubule binding
C	0009897	cellular_component	external side of plasma membrane
C	0009986	cellular_component	cell surface
C	0010955	biological_process	negative regulation of protein processing
C	0014069	cellular_component	postsynaptic density
C	0015631	molecular_function	tubulin binding
C	0016020	cellular_component	membrane
C	0016234	cellular_component	inclusion body
C	0019828	molecular_function	aspartic-type endopeptidase inhibitor activity
C	0019898	cellular_component	extrinsic component of membrane
C	0030425	cellular_component	dendrite
C	0031648	biological_process	protein destabilization
C	0031802	molecular_function	type 5 metabotropic glutamate receptor binding
C	0031805	molecular_function	type 8 metabotropic glutamate receptor binding
C	0031965	cellular_component	nuclear membrane
C	0032147	biological_process	activation of protein kinase activity
C	0032689	biological_process	negative regulation of type II interferon production
C	0032700	biological_process	negative regulation of interleukin-17 production
C	0032703	biological_process	negative regulation of interleukin-2 production
C	0032880	biological_process	regulation of protein localization
C	0038023	molecular_function	signaling receptor activity
C	0042802	molecular_function	identical protein binding
C	0043008	molecular_function	ATP-dependent protein binding
C	0043066	biological_process	negative regulation of apoptotic process
C	0043086	biological_process	negative regulation of catalytic activity
C	0043195	cellular_component	terminal bouton
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0043433	biological_process	negative regulation of DNA-binding transcription factor activity
C	0043525	biological_process	positive regulation of neuron apoptotic process
C	0044325	molecular_function	transmembrane transporter binding
C	0044877	molecular_function	protein-containing complex binding
C	0045121	cellular_component	membrane raft
C	0046007	biological_process	negative regulation of activated T cell proliferation
C	0046686	biological_process	response to cadmium ion
C	0046688	biological_process	response to copper ion
C	0046872	molecular_function	metal ion binding
C	0050730	biological_process	regulation of peptidyl-tyrosine phosphorylation
C	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
C	0050850	biological_process	positive regulation of calcium-mediated signaling
C	0050860	biological_process	negative regulation of T cell receptor signaling pathway
C	0051087	molecular_function	protein-folding chaperone binding
C	0051260	biological_process	protein homooligomerization
C	0051726	biological_process	regulation of cell cycle
C	0060090	molecular_function	molecular adaptor activity
C	0070062	cellular_component	extracellular exosome
C	0070885	biological_process	negative regulation of calcineurin-NFAT signaling cascade
C	0071280	biological_process	cellular response to copper ion
C	0071466	biological_process	cellular response to xenobiotic stimulus
C	0090314	biological_process	positive regulation of protein targeting to membrane
C	0097062	biological_process	dendritic spine maintenance
C	0098552	cellular_component	side of membrane
C	0098794	cellular_component	postsynapse
C	0140677	molecular_function	molecular function activator activity
C	0140693	molecular_function	molecular condensate scaffold activity
C	1900272	biological_process	negative regulation of long-term synaptic potentiation
C	1900449	biological_process	regulation of glutamate receptor signaling pathway
C	1900451	biological_process	positive regulation of glutamate receptor signaling pathway
C	1901379	biological_process	regulation of potassium ion transmembrane transport
C	1902430	biological_process	negative regulation of amyloid-beta formation
C	1902951	biological_process	negative regulation of dendritic spine maintenance
C	1902992	biological_process	negative regulation of amyloid precursor protein catabolic process
C	1903078	biological_process	positive regulation of protein localization to plasma membrane
C	1903135	molecular_function	cupric ion binding
C	1903136	molecular_function	cuprous ion binding
C	1904645	biological_process	response to amyloid-beta
C	1904646	biological_process	cellular response to amyloid-beta
C	1905664	biological_process	regulation of calcium ion import across plasma membrane
C	1990535	biological_process	neuron projection maintenance
D	0001540	molecular_function	amyloid-beta binding
D	0001933	biological_process	negative regulation of protein phosphorylation
D	0002020	molecular_function	protease binding
D	0005507	molecular_function	copper ion binding
D	0005515	molecular_function	protein binding
D	0005521	molecular_function	lamin binding
D	0005539	molecular_function	glycosaminoglycan binding
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006878	biological_process	intracellular copper ion homeostasis
D	0006979	biological_process	response to oxidative stress
D	0007611	biological_process	learning or memory
D	0007616	biological_process	long-term memory
D	0008017	molecular_function	microtubule binding
D	0009897	cellular_component	external side of plasma membrane
D	0009986	cellular_component	cell surface
D	0010955	biological_process	negative regulation of protein processing
D	0014069	cellular_component	postsynaptic density
D	0015631	molecular_function	tubulin binding
D	0016020	cellular_component	membrane
D	0016234	cellular_component	inclusion body
D	0019828	molecular_function	aspartic-type endopeptidase inhibitor activity
D	0019898	cellular_component	extrinsic component of membrane
D	0030425	cellular_component	dendrite
D	0031648	biological_process	protein destabilization
D	0031802	molecular_function	type 5 metabotropic glutamate receptor binding
D	0031805	molecular_function	type 8 metabotropic glutamate receptor binding
D	0031965	cellular_component	nuclear membrane
D	0032147	biological_process	activation of protein kinase activity
D	0032689	biological_process	negative regulation of type II interferon production
D	0032700	biological_process	negative regulation of interleukin-17 production
D	0032703	biological_process	negative regulation of interleukin-2 production
D	0032880	biological_process	regulation of protein localization
D	0038023	molecular_function	signaling receptor activity
D	0042802	molecular_function	identical protein binding
D	0043008	molecular_function	ATP-dependent protein binding
D	0043066	biological_process	negative regulation of apoptotic process
D	0043086	biological_process	negative regulation of catalytic activity
D	0043195	cellular_component	terminal bouton
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0043433	biological_process	negative regulation of DNA-binding transcription factor activity
D	0043525	biological_process	positive regulation of neuron apoptotic process
D	0044325	molecular_function	transmembrane transporter binding
D	0044877	molecular_function	protein-containing complex binding
D	0045121	cellular_component	membrane raft
D	0046007	biological_process	negative regulation of activated T cell proliferation
D	0046686	biological_process	response to cadmium ion
D	0046688	biological_process	response to copper ion
D	0046872	molecular_function	metal ion binding
D	0050730	biological_process	regulation of peptidyl-tyrosine phosphorylation
D	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
D	0050850	biological_process	positive regulation of calcium-mediated signaling
D	0050860	biological_process	negative regulation of T cell receptor signaling pathway
D	0051087	molecular_function	protein-folding chaperone binding
D	0051260	biological_process	protein homooligomerization
D	0051726	biological_process	regulation of cell cycle
D	0060090	molecular_function	molecular adaptor activity
D	0070062	cellular_component	extracellular exosome
D	0070885	biological_process	negative regulation of calcineurin-NFAT signaling cascade
D	0071280	biological_process	cellular response to copper ion
D	0071466	biological_process	cellular response to xenobiotic stimulus
D	0090314	biological_process	positive regulation of protein targeting to membrane
D	0097062	biological_process	dendritic spine maintenance
D	0098552	cellular_component	side of membrane
D	0098794	cellular_component	postsynapse
D	0140677	molecular_function	molecular function activator activity
D	0140693	molecular_function	molecular condensate scaffold activity
D	1900272	biological_process	negative regulation of long-term synaptic potentiation
D	1900449	biological_process	regulation of glutamate receptor signaling pathway
D	1900451	biological_process	positive regulation of glutamate receptor signaling pathway
D	1901379	biological_process	regulation of potassium ion transmembrane transport
D	1902430	biological_process	negative regulation of amyloid-beta formation
D	1902951	biological_process	negative regulation of dendritic spine maintenance
D	1902992	biological_process	negative regulation of amyloid precursor protein catabolic process
D	1903078	biological_process	positive regulation of protein localization to plasma membrane
D	1903135	molecular_function	cupric ion binding
D	1903136	molecular_function	cuprous ion binding
D	1904645	biological_process	response to amyloid-beta
D	1904646	biological_process	cellular response to amyloid-beta
D	1905664	biological_process	regulation of calcium ion import across plasma membrane
D	1990535	biological_process	neuron projection maintenance
E	0001540	molecular_function	amyloid-beta binding
E	0001933	biological_process	negative regulation of protein phosphorylation
E	0002020	molecular_function	protease binding
E	0005507	molecular_function	copper ion binding
E	0005515	molecular_function	protein binding
E	0005521	molecular_function	lamin binding
E	0005539	molecular_function	glycosaminoglycan binding
E	0005737	cellular_component	cytoplasm
E	0005783	cellular_component	endoplasmic reticulum
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006878	biological_process	intracellular copper ion homeostasis
E	0006979	biological_process	response to oxidative stress
E	0007611	biological_process	learning or memory
E	0007616	biological_process	long-term memory
E	0008017	molecular_function	microtubule binding
E	0009897	cellular_component	external side of plasma membrane
E	0009986	cellular_component	cell surface
E	0010955	biological_process	negative regulation of protein processing
E	0014069	cellular_component	postsynaptic density
E	0015631	molecular_function	tubulin binding
E	0016020	cellular_component	membrane
E	0016234	cellular_component	inclusion body
E	0019828	molecular_function	aspartic-type endopeptidase inhibitor activity
E	0019898	cellular_component	extrinsic component of membrane
E	0030425	cellular_component	dendrite
E	0031648	biological_process	protein destabilization
E	0031802	molecular_function	type 5 metabotropic glutamate receptor binding
E	0031805	molecular_function	type 8 metabotropic glutamate receptor binding
E	0031965	cellular_component	nuclear membrane
E	0032147	biological_process	activation of protein kinase activity
E	0032689	biological_process	negative regulation of type II interferon production
E	0032700	biological_process	negative regulation of interleukin-17 production
E	0032703	biological_process	negative regulation of interleukin-2 production
E	0032880	biological_process	regulation of protein localization
E	0038023	molecular_function	signaling receptor activity
E	0042802	molecular_function	identical protein binding
E	0043008	molecular_function	ATP-dependent protein binding
E	0043066	biological_process	negative regulation of apoptotic process
E	0043086	biological_process	negative regulation of catalytic activity
E	0043195	cellular_component	terminal bouton
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0043433	biological_process	negative regulation of DNA-binding transcription factor activity
E	0043525	biological_process	positive regulation of neuron apoptotic process
E	0044325	molecular_function	transmembrane transporter binding
E	0044877	molecular_function	protein-containing complex binding
E	0045121	cellular_component	membrane raft
E	0046007	biological_process	negative regulation of activated T cell proliferation
E	0046686	biological_process	response to cadmium ion
E	0046688	biological_process	response to copper ion
E	0046872	molecular_function	metal ion binding
E	0050730	biological_process	regulation of peptidyl-tyrosine phosphorylation
E	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
E	0050850	biological_process	positive regulation of calcium-mediated signaling
E	0050860	biological_process	negative regulation of T cell receptor signaling pathway
E	0051087	molecular_function	protein-folding chaperone binding
E	0051260	biological_process	protein homooligomerization
E	0051726	biological_process	regulation of cell cycle
E	0060090	molecular_function	molecular adaptor activity
E	0070062	cellular_component	extracellular exosome
E	0070885	biological_process	negative regulation of calcineurin-NFAT signaling cascade
E	0071280	biological_process	cellular response to copper ion
E	0071466	biological_process	cellular response to xenobiotic stimulus
E	0090314	biological_process	positive regulation of protein targeting to membrane
E	0097062	biological_process	dendritic spine maintenance
E	0098552	cellular_component	side of membrane
E	0098794	cellular_component	postsynapse
E	0140677	molecular_function	molecular function activator activity
E	0140693	molecular_function	molecular condensate scaffold activity
E	1900272	biological_process	negative regulation of long-term synaptic potentiation
E	1900449	biological_process	regulation of glutamate receptor signaling pathway
E	1900451	biological_process	positive regulation of glutamate receptor signaling pathway
E	1901379	biological_process	regulation of potassium ion transmembrane transport
E	1902430	biological_process	negative regulation of amyloid-beta formation
E	1902951	biological_process	negative regulation of dendritic spine maintenance
E	1902992	biological_process	negative regulation of amyloid precursor protein catabolic process
E	1903078	biological_process	positive regulation of protein localization to plasma membrane
E	1903135	molecular_function	cupric ion binding
E	1903136	molecular_function	cuprous ion binding
E	1904645	biological_process	response to amyloid-beta
E	1904646	biological_process	cellular response to amyloid-beta
E	1905664	biological_process	regulation of calcium ion import across plasma membrane
E	1990535	biological_process	neuron projection maintenance
F	0001540	molecular_function	amyloid-beta binding
F	0001933	biological_process	negative regulation of protein phosphorylation
F	0002020	molecular_function	protease binding
F	0005507	molecular_function	copper ion binding
F	0005515	molecular_function	protein binding
F	0005521	molecular_function	lamin binding
F	0005539	molecular_function	glycosaminoglycan binding
F	0005737	cellular_component	cytoplasm
F	0005783	cellular_component	endoplasmic reticulum
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006878	biological_process	intracellular copper ion homeostasis
F	0006979	biological_process	response to oxidative stress
F	0007611	biological_process	learning or memory
F	0007616	biological_process	long-term memory
F	0008017	molecular_function	microtubule binding
F	0009897	cellular_component	external side of plasma membrane
F	0009986	cellular_component	cell surface
F	0010955	biological_process	negative regulation of protein processing
F	0014069	cellular_component	postsynaptic density
F	0015631	molecular_function	tubulin binding
F	0016020	cellular_component	membrane
F	0016234	cellular_component	inclusion body
F	0019828	molecular_function	aspartic-type endopeptidase inhibitor activity
F	0019898	cellular_component	extrinsic component of membrane
F	0030425	cellular_component	dendrite
F	0031648	biological_process	protein destabilization
F	0031802	molecular_function	type 5 metabotropic glutamate receptor binding
F	0031805	molecular_function	type 8 metabotropic glutamate receptor binding
F	0031965	cellular_component	nuclear membrane
F	0032147	biological_process	activation of protein kinase activity
F	0032689	biological_process	negative regulation of type II interferon production
F	0032700	biological_process	negative regulation of interleukin-17 production
F	0032703	biological_process	negative regulation of interleukin-2 production
F	0032880	biological_process	regulation of protein localization
F	0038023	molecular_function	signaling receptor activity
F	0042802	molecular_function	identical protein binding
F	0043008	molecular_function	ATP-dependent protein binding
F	0043066	biological_process	negative regulation of apoptotic process
F	0043086	biological_process	negative regulation of catalytic activity
F	0043195	cellular_component	terminal bouton
F	0043231	cellular_component	intracellular membrane-bounded organelle
F	0043433	biological_process	negative regulation of DNA-binding transcription factor activity
F	0043525	biological_process	positive regulation of neuron apoptotic process
F	0044325	molecular_function	transmembrane transporter binding
F	0044877	molecular_function	protein-containing complex binding
F	0045121	cellular_component	membrane raft
F	0046007	biological_process	negative regulation of activated T cell proliferation
F	0046686	biological_process	response to cadmium ion
F	0046688	biological_process	response to copper ion
F	0046872	molecular_function	metal ion binding
F	0050730	biological_process	regulation of peptidyl-tyrosine phosphorylation
F	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
F	0050850	biological_process	positive regulation of calcium-mediated signaling
F	0050860	biological_process	negative regulation of T cell receptor signaling pathway
F	0051087	molecular_function	protein-folding chaperone binding
F	0051260	biological_process	protein homooligomerization
F	0051726	biological_process	regulation of cell cycle
F	0060090	molecular_function	molecular adaptor activity
F	0070062	cellular_component	extracellular exosome
F	0070885	biological_process	negative regulation of calcineurin-NFAT signaling cascade
F	0071280	biological_process	cellular response to copper ion
F	0071466	biological_process	cellular response to xenobiotic stimulus
F	0090314	biological_process	positive regulation of protein targeting to membrane
F	0097062	biological_process	dendritic spine maintenance
F	0098552	cellular_component	side of membrane
F	0098794	cellular_component	postsynapse
F	0140677	molecular_function	molecular function activator activity
F	0140693	molecular_function	molecular condensate scaffold activity
F	1900272	biological_process	negative regulation of long-term synaptic potentiation
F	1900449	biological_process	regulation of glutamate receptor signaling pathway
F	1900451	biological_process	positive regulation of glutamate receptor signaling pathway
F	1901379	biological_process	regulation of potassium ion transmembrane transport
F	1902430	biological_process	negative regulation of amyloid-beta formation
F	1902951	biological_process	negative regulation of dendritic spine maintenance
F	1902992	biological_process	negative regulation of amyloid precursor protein catabolic process
F	1903078	biological_process	positive regulation of protein localization to plasma membrane
F	1903135	molecular_function	cupric ion binding
F	1903136	molecular_function	cuprous ion binding
F	1904645	biological_process	response to amyloid-beta
F	1904646	biological_process	cellular response to amyloid-beta
F	1905664	biological_process	regulation of calcium ion import across plasma membrane
F	1990535	biological_process	neuron projection maintenance

Functional Information from PROSITE/UniProt

site_id	PS00291
Number of Residues	16
Details	PRION_1 Prion protein signature 1. AGAAAAGAVVGGLGGY

Chain	Residue	Details
A	ALA113-TYR128

---

site_id	PS00706
Number of Residues	19
Details	PRION_2 Prion protein signature 2. EtDvKMMeRVVeQMCitQY

Chain	Residue	Details
A	GLU200-TYR218

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:11900542

Chain	Residue	Details
A	HIS61
D	HIS61
D	GLY62
D	GLY63
E	HIS61
E	GLY62
E	GLY63
F	HIS61
F	GLY62
F	GLY63
A	GLY62
A	GLY63
B	HIS61
B	GLY62
B	GLY63
C	HIS61
C	GLY62
C	GLY63

---

site_id	SWS_FT_FI2
Number of Residues	54
Details	BINDING: BINDING => ECO:0000305|PubMed:11900542

Chain	Residue	Details
A	HIS69
B	HIS69
B	GLY70
B	GLY71
B	HIS77
B	GLY78
B	GLY79
B	HIS85
B	GLY86
B	GLY87
C	HIS69
A	GLY70
C	GLY70
C	GLY71
C	HIS77
C	GLY78
C	GLY79
C	HIS85
C	GLY86
C	GLY87
D	HIS69
D	GLY70
A	GLY71
D	GLY71
D	HIS77
D	GLY78
D	GLY79
D	HIS85
D	GLY86
D	GLY87
E	HIS69
E	GLY70
E	GLY71
A	HIS77
E	HIS77
E	GLY78
E	GLY79
E	HIS85
E	GLY86
E	GLY87
F	HIS69
F	GLY70
F	GLY71
F	HIS77
A	GLY78
F	GLY78
F	GLY79
F	HIS85
F	GLY86
F	GLY87
A	GLY79
A	HIS85
A	GLY86
A	GLY87

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	LIPID: GPI-anchor amidated serine => ECO:0000250|UniProtKB:P04273

Chain	Residue	Details
A	SER230
B	SER230
C	SER230
D	SER230
E	SER230
F	SER230

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12214108

Chain	Residue	Details
A	ASN181
B	ASN181
C	ASN181
D	ASN181
E	ASN181
F	ASN181

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973

Chain	Residue	Details
A	ASN197
B	ASN197
C	ASN197
D	ASN197
E	ASN197
F	ASN197

---