7D8X

CryoEM structure of human gamma-secretase in complex with E2012 and L685458

Summary for 7D8X

• Entry DOI: 10.2210/pdb7d8x/pdb
• EMDB information: 30614
• Descriptor: Nicastrin, PHOSPHATIDYLETHANOLAMINE, ~{tert}-butyl ~{N}-[(2~{S},3~{R},5~{R})-6-[[(2~{S})-1-[[(2~{S})-1-azanyl-1-oxidanylidene-3-phenyl-propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]amino]-3-oxidanyl-6-oxidanylidene-1-phenyl-5-(phenylmethyl)hexan-2-yl]carbamate, ... (12 entities in total)
• Functional Keywords: inhibitor, modulator, membrane protein, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 185640.44

Authors

Yang, G.,Zhou, R.,Guo, X.,Lei, J.,Yan, C.,Shi, Y. (deposition date: 2020-10-11, release date: 2021-01-27, Last modification date: 2021-02-03)

• Primary citation: Yang, G.,Zhou, R.,Guo, X.,Yan, C.,Lei, J.,Shi, Y.; Structural basis of gamma-secretase inhibition and modulation by small molecule drugs.; Cell, 184:521-533.e14, 2021; PubMed: 33373587; DOI: 10.1016/j.cell.2020.11.049

Experimental method

ELECTRON MICROSCOPY (2.6 Å)