8K8E

Human gamma-secretase in complex with a substrate mimetic

Summary for 8K8E

• Entry DOI: 10.2210/pdb8k8e/pdb
• EMDB information: 36948
• Descriptor: Nicastrin, CHOLESTEROL, Presenilin-1, ... (10 entities in total)
• Functional Keywords: complex, protease, substrate mimetic, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 178324.58

Authors

Shi, Y.G.,Zhou, R.,Wolfe, M.S. (deposition date: 2023-07-29, release date: 2024-01-31, Last modification date: 2024-02-28)

• Primary citation: Devkota, S.,Zhou, R.,Nagarajan, V.,Maesako, M.,Do, H.,Noorani, A.,Overmeyer, C.,Bhattarai, S.,Douglas, J.T.,Saraf, A.,Miao, Y.,Ackley, B.D.,Shi, Y.,Wolfe, M.S.; Familial Alzheimer mutations stabilize synaptotoxic gamma-secretase-substrate complexes.; Cell Rep, 43:113761-113761, 2024; PubMed: 38349793; DOI: 10.1016/j.celrep.2024.113761

Experimental method

ELECTRON MICROSCOPY (2.6 Å)