8K8E
Human gamma-secretase in complex with a substrate mimetic
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Nicastrin | polymer | 709 | 78483.6 | 1 | UniProt (Q92542) Pfam (PF18266) Pfam (PF05450) | Homo sapiens (human) | |
| 2 | B (B) | Presenilin-1 | polymer | 467 | 52713.5 | 1 | UniProt (P49768) Pfam (PF01080) | Homo sapiens (human) | PS-1,Protein S182 |
| 3 | C (C) | Gamma-secretase subunit APH-1A | polymer | 265 | 29017.9 | 1 | UniProt (Q96BI3) Pfam (PF06105) | Homo sapiens (human) | APH-1a,Aph-1alpha,Presenilin-stabilization factor |
| 4 | D (D) | Gamma-secretase subunit PEN-2 | polymer | 101 | 12038.0 | 1 | UniProt (Q9NZ42) Pfam (PF10251) | Homo sapiens (human) | Presenilin enhancer protein 2 |
| 5 | E (H) | ZQN-GLY-AIB-VAL-VAL-ILE-AIB-PHE-VAL-AIB-GLY-GLY-GLY-VAL-JUU-LEU-VAL-NH2 | polymer | 18 | 1864.3 | 1 | synthetic construct | ||
| 6 | F (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 7 | G (F) | beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose | branched | 504.4 | 1 | In PDB GlyTouCan (G59712QJ) | |||
| 8 | H, I, J, K, L... (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 9 | N (B) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 1 | Chemie (PC1) | |||
| 10 | O, P, Q (C) | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 174117.4 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 928.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 3277.4 | |
| All* | Total formula weight | 178323.6 |
