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1XN3

Crystal structure of Beta-secretase bound to a long inhibitor with additional upstream residues.

Summary for 1XN3
Entry DOI10.2210/pdb1xn3/pdb
Related1FKN 1M4H 1SGZ 1XN2
DescriptorBeta-secretase 1, Peptidic inhibitor (3 entities in total)
Functional Keywordsbace, alzheimer's disease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein: P56817
Total number of polymer chains5
Total formula weight174904.04
Authors
Turner III, R.T.,Hong, L.,Koelsch, G.,Ghosh, A.K.,Tang, J. (deposition date: 2004-10-04, release date: 2005-03-22, Last modification date: 2023-11-15)
Primary citationTurner III, R.T.,Hong, L.,Koelsch, G.,Ghosh, A.K.,Tang, J.
Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase).
Biochemistry, 44:105-112, 2005
Cited by
PubMed: 15628850
DOI: 10.1021/bi048106k
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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