1XN3
Crystal structure of Beta-secretase bound to a long inhibitor with additional upstream residues.
Summary for 1XN3
Entry DOI | 10.2210/pdb1xn3/pdb |
Related | 1FKN 1M4H 1SGZ 1XN2 |
Descriptor | Beta-secretase 1, Peptidic inhibitor (3 entities in total) |
Functional Keywords | bace, alzheimer's disease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 5 |
Total formula weight | 174904.04 |
Authors | Turner III, R.T.,Hong, L.,Koelsch, G.,Ghosh, A.K.,Tang, J. (deposition date: 2004-10-04, release date: 2005-03-22, Last modification date: 2023-11-15) |
Primary citation | Turner III, R.T.,Hong, L.,Koelsch, G.,Ghosh, A.K.,Tang, J. Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase). Biochemistry, 44:105-112, 2005 Cited by PubMed: 15628850DOI: 10.1021/bi048106k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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