7VC3
 
 | | Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor L97 and L-proline at 1.97 A resolution | | Descriptor: | 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, CHLORIDE ION, ETHANOLAMINE, ... | | Authors: | Malhotra, N, Yogavel, M, Sharma, A. | | Deposit date: | 2021-09-01 | | Release date: | 2022-09-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.973 Å) | | Cite: | Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
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8SV8
 | | Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex from a composite map | | Descriptor: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | | Authors: | Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-11 | | Method: | ELECTRON MICROSCOPY (3.38 Å) | | Cite: | Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Nat Commun, 14, 2023
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4JFA
 | | Crystal Structure of Plasmodium falciparum Tryptophanyl-tRNA synthetase | | Descriptor: | BETA-MERCAPTOETHANOL, POTASSIUM ION, TRYPTOPHAN, ... | | Authors: | Khan, S, Garg, A, Manickam, Y, Sharma, A. | | Deposit date: | 2013-02-28 | | Release date: | 2014-01-29 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | An appended domain results in an unusual architecture for malaria parasite tryptophanyl-tRNA synthetase
Plos One, 8, 2013
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1JAT
 | | Mms2/Ubc13 Ubiquitin Conjugating Enzyme Complex | | Descriptor: | Ubiquitin-Conjugating Enzyme E2-17.5 KDA, Ubiquitin-Conjugating Enzyme Variant Mms2 | | Authors: | VanDemark, A.P, Hofmann, R.M, Tsui, C, Pickart, C.M, Wolberger, C. | | Deposit date: | 2001-05-31 | | Release date: | 2001-06-20 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer.
Cell(Cambridge,Mass.), 105, 2001
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2A0C
 | | Human CDK2 in complex with olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor | | Descriptor: | 2-{[(2-{[(1R)-1-(HYDROXYMETHYL)PROPYL]AMINO}-9-ISOPROPYL-9H-PURIN-6-YL)AMINO]METHYL}PHENOL, Cell division protein kinase 2 | | Authors: | Krystof, V, McNae, I.W, Walkinshaw, M.D, Fischer, P.M, Muller, P, Vojtesek, B, Orsag, M, Havlicek, L, Strnad, M. | | Deposit date: | 2005-06-16 | | Release date: | 2006-01-24 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor
Cell.Mol.Life Sci., 62, 2005
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2FUH
 | | Solution Structure of the UbcH5c/Ub Non-covalent Complex | | Descriptor: | Ubiquitin, Ubiquitin-conjugating enzyme E2 D3 | | Authors: | Brzovic, P.S, Lissounov, A, Hoyt, D.W, Klevit, R.E. | | Deposit date: | 2006-01-26 | | Release date: | 2006-03-28 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | A UbcH5/Ubiquitin Noncovalent Complex Is Required for Processive BRCA1-Directed Ubiquitination.
Mol.Cell, 21, 2006
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6CYO
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6CYR
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3PGE
 | | Structure of sumoylated PCNA | | Descriptor: | Proliferating cell nuclear antigen, SUMO-modified proliferating cell nuclear antigen | | Authors: | Freudenthal, B.D, Brogie, J.E, Gakhar, L, Washington, T. | | Deposit date: | 2010-11-01 | | Release date: | 2010-12-29 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal Structure of SUMO-Modified Proliferating Cell Nuclear Antigen.
J.Mol.Biol., 406, 2011
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6XQJ
 | | Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A | | Descriptor: | Protein Vpr,UV excision repair protein RAD23 homolog A, ZINC ION | | Authors: | Byeon, I.-J.L, Calero, G, Wu, Y, Byeon, C.H, Gronenborn, A.M. | | Deposit date: | 2020-07-09 | | Release date: | 2021-11-17 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A.
Nat Commun, 12, 2021
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8JWS
 | | ePHD domain of PHD Finger Protein 7 (PHF7) | | Descriptor: | 1,2-ETHANEDIOL, PHD finger protein 7, ZINC ION | | Authors: | Bang, I, Lee, H.S, Choi, H.-J. | | Deposit date: | 2023-06-29 | | Release date: | 2023-12-20 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Molecular basis for PHF7-mediated ubiquitination of histone H3.
Genes Dev., 37, 2023
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4BVY
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1GSO
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3K0H
 | | The crystal structure of BRCA1 BRCT in complex with a minimal recognition tetrapeptide with an amidated C-terminus | | Descriptor: | Breast cancer type 1 susceptibility protein, CHLORIDE ION, NICKEL (II) ION, ... | | Authors: | Campbell, S.J, Edwards, R.A, Glover, J.N. | | Deposit date: | 2009-09-24 | | Release date: | 2010-03-02 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1
Structure, 18, 2010
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3K15
 | | Crystal Structure of BRCA1 BRCT D1840T in complex with a minimal recognition tetrapeptide with an amidated C-terminus | | Descriptor: | Breast cancer type 1 susceptibility protein, CHLORIDE ION, NICKEL (II) ION, ... | | Authors: | Campbell, S.J, Edwards, R.A, Glover, J.N. | | Deposit date: | 2009-09-25 | | Release date: | 2010-03-02 | | Last modified: | 2021-10-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1
Structure, 18, 2010
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3K0K
 | | Crystal Structure of BRCA1 BRCT in complex with a minimal recognition tetrapeptide with a free carboxy C-terminus. | | Descriptor: | Breast cancer type 1 susceptibility protein, CHLORIDE ION, NICKEL (II) ION, ... | | Authors: | Campbell, S.J, Edwards, R.A, Glover, J.N. | | Deposit date: | 2009-09-24 | | Release date: | 2010-03-02 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1
Structure, 18, 2010
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1HV2
 | | SOLUTION STRUCTURE OF YEAST ELONGIN C IN COMPLEX WITH A VON HIPPEL-LINDAU PEPTIDE | | Descriptor: | ELONGIN C, VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR | | Authors: | Botuyan, M.V, Mer, G, Yi, G.-S, Koth, C.M, Case, D.A, Edwards, A.M, Chazin, W.J, Arrowsmith, C.H. | | Deposit date: | 2001-01-05 | | Release date: | 2001-09-06 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution structure and dynamics of yeast elongin C in complex with a von Hippel-Lindau peptide.
J.Mol.Biol., 312, 2001
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7WRS
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3K1L
 | | Crystal Structure of FANCL | | Descriptor: | CITRIC ACID, Fancl, GOLD ION, ... | | Authors: | Cole, A.R, Walden, H. | | Deposit date: | 2009-09-28 | | Release date: | 2010-02-16 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | The structure of the catalytic subunit FANCL of the Fanconi anemia core complex
Nat.Struct.Mol.Biol., 17, 2010
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8SZK
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2FIF
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7UOA
 | | MAGEA4-MTP1 linear peptide complex | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MTP-1, ... | | Authors: | Williams, R.S, Tumbale, P.S. | | Deposit date: | 2022-04-12 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Discovery and Structural Basis of the Selectivity of Potent Cyclic Peptide Inhibitors of MAGE-A4.
J.Med.Chem., 65, 2022
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2FID
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4ZDJ
 | | Crystal structure of the M. tuberculosis CTP synthase PyrG in complex with two UTP molecules | | Descriptor: | CTP synthase, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Bellinzoni, M, Barilone, N, Alzari, P.M. | | Deposit date: | 2015-04-17 | | Release date: | 2015-07-01 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.
Chem.Biol., 22, 2015
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4ZDI
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