4ZDI

Crystal structure of the M. tuberculosis CTP synthase PyrG (apo form)

Summary for 4ZDI

• Entry DOI: 10.2210/pdb4zdi/pdb
• Descriptor: CTP synthase, CALCIUM ION (2 entities in total)
• Functional Keywords: ctp synthase, pyrg, amidotransferase, ligase
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 8
• Total formula weight: 510488.25

Authors

Bellinzoni, M.,Barilone, N.,Alzari, P.M. (deposition date: 2015-04-17, release date: 2015-07-01, Last modification date: 2024-01-10)

• Primary citation: Mori, G.,Chiarelli, L.R.,Esposito, M.,Makarov, V.,Bellinzoni, M.,Hartkoorn, R.C.,Degiacomi, G.,Boldrin, F.,Ekins, S.,de Jesus Lopes Ribeiro, A.L.,Marino, L.B.,Centarova, I.,Svetlikova, Z.,Blasko, J.,Kazakova, E.,Lepioshkin, A.,Barilone, N.,Zanoni, G.,Porta, A.,Fondi, M.,Fani, R.,Baulard, A.R.,Mikusova, K.,Alzari, P.M.,Manganelli, R.,de Carvalho, L.P.,Riccardi, G.,Cole, S.T.,Pasca, M.R.; Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.; Chem.Biol., 22:917-927, 2015; PubMed: 26097035; DOI: 10.1016/j.chembiol.2015.05.016

Experimental method

X-RAY DIFFRACTION (3.52 Å)