4ZDI

Crystal structure of the M. tuberculosis CTP synthase PyrG (apo form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003883	molecular_function	CTP synthase activity
A	0004359	molecular_function	glutaminase activity
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0016874	molecular_function	ligase activity
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0097268	cellular_component	cytoophidium
B	0000166	molecular_function	nucleotide binding
B	0003883	molecular_function	CTP synthase activity
B	0004359	molecular_function	glutaminase activity
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0016874	molecular_function	ligase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0044210	biological_process	'de novo' CTP biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0097268	cellular_component	cytoophidium
C	0000166	molecular_function	nucleotide binding
C	0003883	molecular_function	CTP synthase activity
C	0004359	molecular_function	glutaminase activity
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0016874	molecular_function	ligase activity
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0042802	molecular_function	identical protein binding
C	0044210	biological_process	'de novo' CTP biosynthetic process
C	0046872	molecular_function	metal ion binding
C	0097268	cellular_component	cytoophidium
D	0000166	molecular_function	nucleotide binding
D	0003883	molecular_function	CTP synthase activity
D	0004359	molecular_function	glutaminase activity
D	0005524	molecular_function	ATP binding
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006241	biological_process	CTP biosynthetic process
D	0016874	molecular_function	ligase activity
D	0019856	biological_process	pyrimidine nucleobase biosynthetic process
D	0042802	molecular_function	identical protein binding
D	0044210	biological_process	'de novo' CTP biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0097268	cellular_component	cytoophidium
E	0000166	molecular_function	nucleotide binding
E	0003883	molecular_function	CTP synthase activity
E	0004359	molecular_function	glutaminase activity
E	0005524	molecular_function	ATP binding
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006241	biological_process	CTP biosynthetic process
E	0016874	molecular_function	ligase activity
E	0019856	biological_process	pyrimidine nucleobase biosynthetic process
E	0042802	molecular_function	identical protein binding
E	0044210	biological_process	'de novo' CTP biosynthetic process
E	0046872	molecular_function	metal ion binding
E	0097268	cellular_component	cytoophidium
F	0000166	molecular_function	nucleotide binding
F	0003883	molecular_function	CTP synthase activity
F	0004359	molecular_function	glutaminase activity
F	0005524	molecular_function	ATP binding
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006241	biological_process	CTP biosynthetic process
F	0016874	molecular_function	ligase activity
F	0019856	biological_process	pyrimidine nucleobase biosynthetic process
F	0042802	molecular_function	identical protein binding
F	0044210	biological_process	'de novo' CTP biosynthetic process
F	0046872	molecular_function	metal ion binding
F	0097268	cellular_component	cytoophidium
G	0000166	molecular_function	nucleotide binding
G	0003883	molecular_function	CTP synthase activity
G	0004359	molecular_function	glutaminase activity
G	0005524	molecular_function	ATP binding
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006221	biological_process	pyrimidine nucleotide biosynthetic process
G	0006241	biological_process	CTP biosynthetic process
G	0016874	molecular_function	ligase activity
G	0019856	biological_process	pyrimidine nucleobase biosynthetic process
G	0042802	molecular_function	identical protein binding
G	0044210	biological_process	'de novo' CTP biosynthetic process
G	0046872	molecular_function	metal ion binding
G	0097268	cellular_component	cytoophidium
H	0000166	molecular_function	nucleotide binding
H	0003883	molecular_function	CTP synthase activity
H	0004359	molecular_function	glutaminase activity
H	0005524	molecular_function	ATP binding
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0006241	biological_process	CTP biosynthetic process
H	0016874	molecular_function	ligase activity
H	0019856	biological_process	pyrimidine nucleobase biosynthetic process
H	0042802	molecular_function	identical protein binding
H	0044210	biological_process	'de novo' CTP biosynthetic process
H	0046872	molecular_function	metal ion binding
H	0097268	cellular_component	cytoophidium

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue CA A 601

Chain	Residue
A	HIS63
A	ASP76
A	LEU77

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CA B 601

Chain	Residue
B	HIS63
B	ASP76
B	LEU77

---

site_id	AC3
Number of Residues	3
Details	binding site for residue CA C 601

Chain	Residue
C	HIS63
C	ASP76
C	LEU77

---

site_id	AC4
Number of Residues	3
Details	binding site for residue CA D 601

Chain	Residue
D	HIS63
D	ASP76
D	LEU77

---

site_id	AC5
Number of Residues	2
Details	binding site for residue CA E 601

Chain	Residue
E	ASP76
E	LEU77

---

site_id	AC6
Number of Residues	1
Details	binding site for residue CA F 601

Chain	Residue
F	ASP76

---

site_id	AC7
Number of Residues	3
Details	binding site for residue CA G 601

Chain	Residue
G	HIS63
G	ASP76
G	LEU77

---

site_id	AC8
Number of Residues	2
Details	binding site for residue CA H 601

Chain	Residue
H	ASP76
H	LEU77

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Nucleophile; for glutamine hydrolysis","evidences":[{"source":"HAMAP-Rule","id":"MF_01227","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26097035","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01227","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26097035","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	52
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26097035","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	112
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01227","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P0A7E5","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"26097035","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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