Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4ZDI

Crystal structure of the M. tuberculosis CTP synthase PyrG (apo form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003883	molecular_function	CTP synthase activity
A	0004359	molecular_function	glutaminase activity
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0016874	molecular_function	ligase activity
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0097268	cellular_component	cytoophidium
B	0000166	molecular_function	nucleotide binding
B	0003883	molecular_function	CTP synthase activity
B	0004359	molecular_function	glutaminase activity
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0016874	molecular_function	ligase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0044210	biological_process	'de novo' CTP biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0097268	cellular_component	cytoophidium
C	0000166	molecular_function	nucleotide binding
C	0003883	molecular_function	CTP synthase activity
C	0004359	molecular_function	glutaminase activity
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0016874	molecular_function	ligase activity
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0042802	molecular_function	identical protein binding
C	0044210	biological_process	'de novo' CTP biosynthetic process
C	0046872	molecular_function	metal ion binding
C	0097268	cellular_component	cytoophidium
D	0000166	molecular_function	nucleotide binding
D	0003883	molecular_function	CTP synthase activity
D	0004359	molecular_function	glutaminase activity
D	0005524	molecular_function	ATP binding
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006241	biological_process	CTP biosynthetic process
D	0016874	molecular_function	ligase activity
D	0019856	biological_process	pyrimidine nucleobase biosynthetic process
D	0042802	molecular_function	identical protein binding
D	0044210	biological_process	'de novo' CTP biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0097268	cellular_component	cytoophidium
E	0000166	molecular_function	nucleotide binding
E	0003883	molecular_function	CTP synthase activity
E	0004359	molecular_function	glutaminase activity
E	0005524	molecular_function	ATP binding
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006241	biological_process	CTP biosynthetic process
E	0016874	molecular_function	ligase activity
E	0019856	biological_process	pyrimidine nucleobase biosynthetic process
E	0042802	molecular_function	identical protein binding
E	0044210	biological_process	'de novo' CTP biosynthetic process
E	0046872	molecular_function	metal ion binding
E	0097268	cellular_component	cytoophidium
F	0000166	molecular_function	nucleotide binding
F	0003883	molecular_function	CTP synthase activity
F	0004359	molecular_function	glutaminase activity
F	0005524	molecular_function	ATP binding
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006241	biological_process	CTP biosynthetic process
F	0016874	molecular_function	ligase activity
F	0019856	biological_process	pyrimidine nucleobase biosynthetic process
F	0042802	molecular_function	identical protein binding
F	0044210	biological_process	'de novo' CTP biosynthetic process
F	0046872	molecular_function	metal ion binding
F	0097268	cellular_component	cytoophidium
G	0000166	molecular_function	nucleotide binding
G	0003883	molecular_function	CTP synthase activity
G	0004359	molecular_function	glutaminase activity
G	0005524	molecular_function	ATP binding
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006221	biological_process	pyrimidine nucleotide biosynthetic process
G	0006241	biological_process	CTP biosynthetic process
G	0016874	molecular_function	ligase activity
G	0019856	biological_process	pyrimidine nucleobase biosynthetic process
G	0042802	molecular_function	identical protein binding
G	0044210	biological_process	'de novo' CTP biosynthetic process
G	0046872	molecular_function	metal ion binding
G	0097268	cellular_component	cytoophidium
H	0000166	molecular_function	nucleotide binding
H	0003883	molecular_function	CTP synthase activity
H	0004359	molecular_function	glutaminase activity
H	0005524	molecular_function	ATP binding
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0006241	biological_process	CTP biosynthetic process
H	0016874	molecular_function	ligase activity
H	0019856	biological_process	pyrimidine nucleobase biosynthetic process
H	0042802	molecular_function	identical protein binding
H	0044210	biological_process	'de novo' CTP biosynthetic process
H	0046872	molecular_function	metal ion binding
H	0097268	cellular_component	cytoophidium

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue CA A 601

Chain	Residue
A	HIS63
A	ASP76
A	LEU77

site_id	AC2
Number of Residues	3
Details	binding site for residue CA B 601

Chain	Residue
B	HIS63
B	ASP76
B	LEU77

site_id	AC3
Number of Residues	3
Details	binding site for residue CA C 601

Chain	Residue
C	HIS63
C	ASP76
C	LEU77

site_id	AC4
Number of Residues	3
Details	binding site for residue CA D 601

Chain	Residue
D	HIS63
D	ASP76
D	LEU77

site_id	AC5
Number of Residues	2
Details	binding site for residue CA E 601

Chain	Residue
E	ASP76
E	LEU77

site_id	AC6
Number of Residues	1
Details	binding site for residue CA F 601

Chain	Residue
F	ASP76

site_id	AC7
Number of Residues	3
Details	binding site for residue CA G 601

Chain	Residue
G	HIS63
G	ASP76
G	LEU77

site_id	AC8
Number of Residues	2
Details	binding site for residue CA H 601

Chain	Residue
H	ASP76
H	LEU77

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Nucleophile; for glutamine hydrolysis => ECO:0000255\|HAMAP-Rule:MF_01227, ECO:0000269\|PubMed:26097035

Chain	Residue	Details
A	CYS393
B	CYS393
C	CYS393
D	CYS393
E	CYS393
F	CYS393
G	CYS393
H	CYS393

site_id	SWS_FT_FI2
Number of Residues	16
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_01227, ECO:0000305\|PubMed:26097035

Chain	Residue	Details
A	HIS524
E	GLU526
F	HIS524
F	GLU526
G	HIS524
G	GLU526
H	HIS524
H	GLU526
A	GLU526
B	HIS524
B	GLU526
C	HIS524
C	GLU526
D	HIS524
D	GLU526
E	HIS524

site_id	SWS_FT_FI3
Number of Residues	32
Details	BINDING: BINDING => ECO:0000305\|PubMed:26097035

Chain	Residue	Details
A	SER20
C	SER21
C	LYS46
C	ALA253
D	SER20
D	SER21
D	LYS46
D	ALA253
E	SER20
E	SER21
E	LYS46
A	SER21
E	ALA253
F	SER20
F	SER21
F	LYS46
F	ALA253
G	SER20
G	SER21
G	LYS46
G	ALA253
H	SER20
A	LYS46
H	SER21
H	LYS46
H	ALA253
A	ALA253
B	SER20
B	SER21
B	LYS46
B	ALA253
C	SER20

site_id	SWS_FT_FI4
Number of Residues	64
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_01227

Chain	Residue	Details
A	ASP78
B	GLU152
B	LYS199
B	LYS235
B	GLY366
B	LEU394
B	GLU416
B	ARG477
C	ASP78
C	GLU152
C	LYS199
A	GLU152
C	LYS235
C	GLY366
C	LEU394
C	GLU416
C	ARG477
D	ASP78
D	GLU152
D	LYS199
D	LYS235
D	GLY366
A	LYS199
D	LEU394
D	GLU416
D	ARG477
E	ASP78
E	GLU152
E	LYS199
E	LYS235
E	GLY366
E	LEU394
E	GLU416
A	LYS235
E	ARG477
F	ASP78
F	GLU152
F	LYS199
F	LYS235
F	GLY366
F	LEU394
F	GLU416
F	ARG477
G	ASP78
A	GLY366
G	GLU152
G	LYS199
G	LYS235
G	GLY366
G	LEU394
G	GLU416
G	ARG477
H	ASP78
H	GLU152
H	LYS199
A	LEU394
H	LYS235
H	GLY366
H	LEU394
H	GLU416
H	ARG477
A	GLU416
A	ARG477
B	ASP78

site_id	SWS_FT_FI5
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P0A7E5, ECO:0000305\|PubMed:26097035

Chain	Residue	Details
A	ASP159
B	ASP159
C	ASP159
D	ASP159
E	ASP159
F	ASP159
G	ASP159
H	ASP159

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)