4ZDJ

Crystal structure of the M. tuberculosis CTP synthase PyrG in complex with two UTP molecules

Summary for 4ZDJ

Entry DOI	10.2210/pdb4zdj/pdb
Descriptor	CTP synthase, URIDINE 5'-TRIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	ctp synthase, pyrg, amidotransferase, utp, ligase
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	1
Total formula weight	64879.94
Authors	Bellinzoni, M.,Barilone, N.,Alzari, P.M. (deposition date: 2015-04-17, release date: 2015-07-01, Last modification date: 2024-01-10)
Primary citation	Mori, G.,Chiarelli, L.R.,Esposito, M.,Makarov, V.,Bellinzoni, M.,Hartkoorn, R.C.,Degiacomi, G.,Boldrin, F.,Ekins, S.,de Jesus Lopes Ribeiro, A.L.,Marino, L.B.,Centarova, I.,Svetlikova, Z.,Blasko, J.,Kazakova, E.,Lepioshkin, A.,Barilone, N.,Zanoni, G.,Porta, A.,Fondi, M.,Fani, R.,Baulard, A.R.,Mikusova, K.,Alzari, P.M.,Manganelli, R.,de Carvalho, L.P.,Riccardi, G.,Cole, S.T.,Pasca, M.R. Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. Chem.Biol., 22:917-927, 2015 Cited by PubMed: 26097035 DOI: 10.1016/j.chembiol.2015.05.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.99 Å)

Structure validation