4ZHK
 
 | | Crystal structure of RPE65 in complex with MB-002 | | Descriptor: | (1R)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol, (1S)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol, FE (II) ION, ... | | Authors: | Kiser, P.D, Palczewski, K. | | Deposit date: | 2015-04-25 | | Release date: | 2015-05-27 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Molecular pharmacodynamics of emixustat in protection against retinal degeneration.
J.Clin.Invest., 125, 2015
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8FWP
 | | Crystal Structure of CDC10 - CDC3 heterocomplex from Saccharomyces cerevisiae | | Descriptor: | Cell division control protein 10, Cell division control protein 3, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Silva, R.M, Leonardo, D.A, Pereira, H.M, Garratt, R.C. | | Deposit date: | 2023-01-23 | | Release date: | 2023-07-05 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | A key piece of the puzzle: The central tetramer of the Saccharomyces cerevisiae septin protofilament and its implications for self-assembly.
J.Struct.Biol., 215, 2023
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4ZF7
 | | Crystal structure of ferret interleukin-2 | | Descriptor: | DI(HYDROXYETHYL)ETHER, Interleukin 2, PENTAETHYLENE GLYCOL, ... | | Authors: | Ren, B, Newman, J, McKinstry, W.J, Adams, T.E. | | Deposit date: | 2015-04-21 | | Release date: | 2015-11-04 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (1.893 Å) | | Cite: | Structural and functional characterisation of ferret interleukin-2.
Dev.Comp.Immunol., 55, 2015
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4ZNQ
 | | Crystal structure of Dln1 complexed with Man(alpha1-2)Man | | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ... | | Authors: | Jia, N, Jiang, Y.L, Cheng, W, Wang, H.W, Zhou, C.Z, Chen, Y. | | Deposit date: | 2015-05-05 | | Release date: | 2016-01-20 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein.
Embo Rep., 17, 2016
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8V04
 | | High resolution TMPRSS2 structure following acylation by nafamostat | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 4-carbamimidamidobenzoic acid, ... | | Authors: | Fraser, B.J, Dong, A, Kutera, M, Seitova, A, Li, Y, Hutchinson, A, Edwards, A, Benard, F, Levon, H, Arrowsmith, C. | | Deposit date: | 2023-11-16 | | Release date: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | High resolution TMPRSS2 structure following acylation by nafamostat
To Be Published
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8G32
 | | Pro-form of a CDCL short from E. anophelis | | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ... | | Authors: | Johnstone, B.A, Christie, M.P, Morton, C.J, Parker, M.W. | | Deposit date: | 2023-02-06 | | Release date: | 2024-02-07 | | Last modified: | 2024-06-26 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Distant relatives of a eukaryotic cell-specific toxin family evolved a complement-like mechanism to kill bacteria.
Nat Commun, 15, 2024
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6PGL
 | | Structure of Kluyveromyces marxianus Usb1 with uridine monophosphate | | Descriptor: | 1,2-ETHANEDIOL, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, GLYCEROL, ... | | Authors: | Nomura, Y, Montemayor, E.J, Butcher, S.E. | | Deposit date: | 2019-06-24 | | Release date: | 2019-12-11 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.845 Å) | | Cite: | Structural basis for the evolution of cyclic phosphodiesterase activity in the U6 snRNA exoribonuclease Usb1.
Nucleic Acids Res., 48, 2020
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7JL3
 | | Cryo-EM structure of RIG-I:dsRNA filament in complex with RIPLET PrySpry domain (trimer) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Antiviral innate immune response receptor RIG-I, E3 ubiquitin-protein ligase RNF135, ... | | Authors: | Kato, K, Ahmad, S, Hur, S. | | Deposit date: | 2020-07-29 | | Release date: | 2020-12-09 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
Mol.Cell, 81, 2021
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3K0H
 | | The crystal structure of BRCA1 BRCT in complex with a minimal recognition tetrapeptide with an amidated C-terminus | | Descriptor: | Breast cancer type 1 susceptibility protein, CHLORIDE ION, NICKEL (II) ION, ... | | Authors: | Campbell, S.J, Edwards, R.A, Glover, J.N. | | Deposit date: | 2009-09-24 | | Release date: | 2010-03-02 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1
Structure, 18, 2010
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3K15
 | | Crystal Structure of BRCA1 BRCT D1840T in complex with a minimal recognition tetrapeptide with an amidated C-terminus | | Descriptor: | Breast cancer type 1 susceptibility protein, CHLORIDE ION, NICKEL (II) ION, ... | | Authors: | Campbell, S.J, Edwards, R.A, Glover, J.N. | | Deposit date: | 2009-09-25 | | Release date: | 2010-03-02 | | Last modified: | 2021-10-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1
Structure, 18, 2010
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2PK3
 | | Crystal Structure of a GDP-4-keto-6-deoxy-D-mannose reductase | | Descriptor: | GDP-6-deoxy-D-lyxo-4-hexulose reductase, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, [(2R,3R,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3-HYDROXY-4-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL [(2R,3S,4R,5R)-3,4,5-TRIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE | | Authors: | Webb, N.A, Garavito, R.M. | | Deposit date: | 2007-04-17 | | Release date: | 2008-03-25 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | The structural basis for catalytic function of GMD and RMD, two closely related enzymes from the GDP-D-rhamnose biosynthesis pathway.
Febs J., 276, 2009
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8DSW
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3URZ
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3K6O
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8DYD
 | | Crystal structure of human SDHA-SDHAF2-SDHAF4 assembly intermediate | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Sharma, P, Maklashina, E, Cecchini, G, Iverson, T.M. | | Deposit date: | 2022-08-04 | | Release date: | 2024-01-10 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners.
Nat Commun, 15, 2024
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8E0G
 | | Re-refined model of active mu-opioid receptor (PDB 5c1m) as an adduct with BU72 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R,3S,3aR,5aS,6R,11bR,11cS)-3a-methoxy-3,14-dimethyl-2-phenyl-2,3,3a,4,5,6,7,11c-octahydro-1H-6,11b-(epiminoethano)-3,5a-methanonaphtho[2,1-g]indole-1,10-diol, CHOLESTEROL, ... | | Authors: | Munro, T.A. | | Deposit date: | 2022-08-09 | | Release date: | 2023-10-18 | | Last modified: | 2024-09-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Reanalysis of a mu opioid receptor crystal structure reveals a covalent adduct with BU72.
Bmc Biol., 21, 2023
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8V1F
 | | TMPRSS2 complexed with the noncovalent inhibitor 6-amidino-2-napthol | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Fraser, B.J, Dong, A, Kutera, M, Seitova, A, Li, Y, Hutchinson, A, Edwards, A, Benard, F, Halabelian, L, Arrowsmith, C, Structural Genomics Consortium (SGC) | | Deposit date: | 2023-11-20 | | Release date: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | TMPRSS2 complexed with the noncovalent inhibitor 6-amidino-2-napthol
To Be Published
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8EEW
 | | CryoEM of the soluble OPA1 dimer from the GDP-AlFx bound helical assembly on a lipid membrane | | Descriptor: | Dynamin-like 120 kDa protein, form S1, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Nyenhuis, S.B, Wu, X, Stanton, A.E, Strub, M.P, Yim, Y.I, Canagarajah, B, Hinshaw, J.E. | | Deposit date: | 2022-09-07 | | Release date: | 2023-06-28 | | Last modified: | 2023-09-13 | | Method: | ELECTRON MICROSCOPY (5.48 Å) | | Cite: | OPA1 helical structures give perspective to mitochondrial dysfunction.
Nature, 620, 2023
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8V7C
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6OCA
 | | Ricin A chain bound to VHH antibody V2G10 | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Ricin A chain, ... | | Authors: | Rudolph, M.J. | | Deposit date: | 2019-03-22 | | Release date: | 2020-04-01 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.113 Å) | | Cite: | Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site.
J.Mol.Biol., 432, 2020
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4Z4W
 | | Crystal structure of GII.10 P domain in complex with 4.7mM fucose | | Descriptor: | 1,2-ETHANEDIOL, Capsid protein, beta-L-fucopyranose | | Authors: | Koromyslova, A.D, Leuthold, M.M, Hansman, G.S. | | Deposit date: | 2015-04-02 | | Release date: | 2015-05-27 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The sweet quartet: Binding of fucose to the norovirus capsid.
Virology, 483, 2015
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6TGF
 | | Pantoea stewartii WceF is a glycan biofilm modifying enzyme with a bacteriophage tailspike-like parallel beta-helix fold | | Descriptor: | 1,2-ETHANEDIOL, Exopolysaccharide biosynthesis protein, TETRAETHYLENE GLYCOL | | Authors: | Irmscher, T, Roske, Y, Gayk, I, Heinemann, U, Barbirz, S. | | Deposit date: | 2019-11-15 | | Release date: | 2020-11-25 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Pantoea stewartii WceF is a glycan biofilm-modifying enzyme with a bacteriophage tailspike-like fold.
J.Biol.Chem., 296, 2021
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8UI6
 | | X-ray crystal structure of Toxoplasma gondii GalNAc-T3 in complex with UDP-GalNAc, Mn2+, and Muc5AC-3,13 | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, Glycosyl transferase, MANGANESE (II) ION, ... | | Authors: | Kumar, P, Samara, N.L. | | Deposit date: | 2023-10-10 | | Release date: | 2024-05-15 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | A Toxoplasma gondii O-glycosyltransferase that modulates bradyzoite cyst wall rigidity is distinct from host homologues.
Nat Commun, 15, 2024
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6O5I
 | | Menin in complex with MI-3454 | | Descriptor: | DIMETHYL SULFOXIDE, Menin, SULFATE ION, ... | | Authors: | Linhares, B.M, Klossowski, S, Cierpicki, T, Grembecka, J. | | Deposit date: | 2019-03-03 | | Release date: | 2020-01-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.24025619 Å) | | Cite: | Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.
J.Clin.Invest., 130, 2020
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8GJ3
 | | E. coli clamp loader on primed template DNA | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA polymerase III subunit delta, DNA polymerase III subunit delta', ... | | Authors: | Oakley, A.J, Xu, Z.-Q, Dixon, N.E. | | Deposit date: | 2023-03-14 | | Release date: | 2024-03-27 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural characterisation of the complete cycle of sliding clamp loading in Escherichia coli.
Nat Commun, 15, 2024
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