6O5I

Menin in complex with MI-3454

Summary for 6O5I

• Entry DOI: 10.2210/pdb6o5i/pdb
• Descriptor: Menin, ~{N}-[3-[[2-cyano-4-methyl-5-[[4-[[2-(methylamino)-6-[2,2,2-tris(fluoranyl)ethyl]thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]indol-1-yl]methyl]-1-bicyclo[1.1.1]pentanyl]methanamide, DIMETHYL SULFOXIDE, ... (6 entities in total)
• Functional Keywords: menin-inhibitor complex, protein binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 56031.93

Authors

Linhares, B.M.,Klossowski, S.,Cierpicki, T.,Grembecka, J. (deposition date: 2019-03-03, release date: 2020-01-08, Last modification date: 2023-10-11)

• Primary citation: Klossowski, S.,Miao, H.,Kempinska, K.,Wu, T.,Purohit, T.,Kim, E.,Linhares, B.M.,Chen, D.,Jih, G.,Perkey, E.,Huang, H.,He, M.,Wen, B.,Wang, Y.,Yu, K.,Lee, S.C.,Danet-Desnoyers, G.,Trotman, W.,Kandarpa, M.,Cotton, A.,Abdel-Wahab, O.,Lei, H.,Dou, Y.,Guzman, M.,Peterson, L.,Gruber, T.,Choi, S.,Sun, D.,Ren, P.,Li, L.S.,Liu, Y.,Burrows, F.,Maillard, I.,Cierpicki, T.,Grembecka, J.; Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.; J.Clin.Invest., 130:981-997, 2020; PubMed: 31855575; DOI: 10.1172/JCI129126

Experimental method

X-RAY DIFFRACTION (1.24025624626 Å)