6O5I

Menin in complex with MI-3454

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Menin	polymer	489	54600.2	1	UniProt (O00255) Pfam (PF05053)	Homo sapiens (Human)
2	B (A)	~{N}-[3-[[2-cyano-4-methyl-5-[[4-[[2-(methylamino)-6-[2,2,2-tris(fluoranyl)ethyl]thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]indol-1-yl]methyl]-1-bicyclo[1.1.1]pentanyl]methanamide	non-polymer		636.7	1	Chemie (LMY)
3	C, D, E, F (A)	DIMETHYL SULFOXIDE	non-polymer		78.1	4	Chemie (DMS)
4	G, H, I (A)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
5	J (A)	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)
6	K (A)	water	water		18.0	871	Chemie (HOH)

Sequence modifications

A: 1 - 53 (UniProt: O00255)

PDB	External Database	Details
Gly -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag

A: 74 - 386 (UniProt: O00255)
A: 399 - 459 (UniProt: O00255)
A: 537 - 593 (UniProt: O00255)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	54600.2
Non-Polymers*	Number of molecules	9
	Total formula weight	1431.7
All*	Total formula weight	56031.9

*Water molecules are not included.