2PK3

Crystal Structure of a GDP-4-keto-6-deoxy-D-mannose reductase

Summary for 2PK3

• Entry DOI: 10.2210/pdb2pk3/pdb
• Descriptor: GDP-6-deoxy-D-lyxo-4-hexulose reductase, [(2R,3R,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3-HYDROXY-4-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL [(2R,3S,4R,5R)-3,4,5-TRIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, ... (4 entities in total)
• Functional Keywords: sdr, short-chain dehydrogenase/reductase, rossmann fold, oxidoreductase
• Biological source: Aneurinibacillus thermoaerophilus
• Total number of polymer chains: 2
• Total formula weight: 74491.53

Authors

Webb, N.A.,Garavito, R.M. (deposition date: 2007-04-17, release date: 2008-03-25, Last modification date: 2023-08-30)

• Primary citation: King, J.D.,Poon, K.K.,Webb, N.A.,Anderson, E.M.,McNally, D.J.,Brisson, J.R.,Messner, P.,Garavito, R.M.,Lam, J.S.; The structural basis for catalytic function of GMD and RMD, two closely related enzymes from the GDP-D-rhamnose biosynthesis pathway.; Febs J., 276:2686-2700, 2009; PubMed: 19459932; DOI: 10.1111/j.1742-4658.2009.06993.x

Experimental method

X-RAY DIFFRACTION (1.82 Å)