8V04

High resolution TMPRSS2 structure following acylation by nafamostat

Summary for 8V04

• Entry DOI: 10.2210/pdb8v04/pdb
• Descriptor: Transmembrane protease serine 2 non-catalytic chain, Transmembrane protease serine 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: inhibitor complex, protease, viral entry, structural genomics, structural genomics consortium, sgc, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 42238.47

Authors

Fraser, B.J.,Dong, A.,Kutera, M.,Seitova, A.,Li, Y.,Hutchinson, A.,Edwards, A.,Benard, F.,Levon, H.,Arrowsmith, C. (deposition date: 2023-11-16, release date: 2024-01-31, Last modification date: 2024-10-30)

• Primary citation: Fraser, B.J.,Dong, A.,Kutera, M.,Seitova, A.,Li, Y.,Hutchinson, A.,Edwards, A.,Benard, F.,Levon, H.,Arrowsmith, C.; High resolution TMPRSS2 structure following acylation by nafamostat; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.58 Å)