8V04
High resolution TMPRSS2 structure following acylation by nafamostat
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Transmembrane protease serine 2 non-catalytic chain | polymer | 110 | 12264.6 | 1 | UniProt (O15393) Pfam (PF15494) | Homo sapiens (human) | |
| 2 | B (B) | Transmembrane protease serine 2 | polymer | 249 | 27856.7 | 1 | UniProt (O15393) Pfam (PF00089) | Homo sapiens (human) | |
| 3 | C (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 773.7 | 1 | In PDB | |||
| 4 | D, F, G, K, L... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 5 | E (A) | UNKNOWN ATOM OR ION | non-polymer | 179.2 | 1 | Chemie (UNX) | |||
| 6 | H (B) | 4-carbamimidamidobenzoic acid | non-polymer | 179.2 | 1 | Chemie (GBS) | |||
| 7 | I (B) | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 8 | J (B) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 9 | N (B) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 10 | R, S (A, B) | water | water | 18.0 | 320 | Chemie (HOH) |
Sequence modifications
A: 148 - 255 (UniProt: O15393)
B: 256 - 492 (UniProt: O15393)
| PDB | External Database | Details |
|---|---|---|
| Ala 146 | - | expression tag |
| Ala 147 | - | expression tag |
| Asp 251 | Ser 251 | engineered mutation |
| Asp 252 | Arg 252 | engineered mutation |
| Asp 253 | Gln 253 | engineered mutation |
| Asp 254 | Ser 254 | engineered mutation |
| Lys 255 | Arg 255 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Glu 493 | - | expression tag |
| Phe 494 | - | expression tag |
| Val 495 | - | expression tag |
| Glu 496 | - | expression tag |
| His 497 | - | expression tag |
| His 498 | - | expression tag |
| His 499 | - | expression tag |
| His 500 | - | expression tag |
| His 501 | - | expression tag |
| His 502 | - | expression tag |
| His 503 | - | expression tag |
| His 504 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 40121.3 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 773.7 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1343.4 | |
| All* | Total formula weight | 42238.5 |
