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8V04

High resolution TMPRSS2 structure following acylation by nafamostat

Functional Information from GO Data
ChainGOidnamespacecontents
A0016020cellular_componentmembrane
B0004252molecular_functionserine-type endopeptidase activity
B0006508biological_processproteolysis
Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC
ChainResidueDetails
BVAL292-CYS297

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV
ChainResidueDetails
BASP435-VAL446

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Charge relay system => ECO:0000250
ChainResidueDetails
BHIS296
BASP345

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Charge relay system
ChainResidueDetails
BSER441
AASN249

227561

PDB entries from 2024-11-20

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