3GKW
 
 | | Crystal structure of the Fab fragment of Nimotuzumab. An anti-epidermal growth factor receptor antibody | | Descriptor: | DI(HYDROXYETHYL)ETHER, Heavy chain of the antibody Nimotuzumab, Light chain of the antibody Nimotuzumab, ... | | Authors: | Talavera, A, Friemann, R, Martinez-Fleites, C, Moreno, E, Krengel, U. | | Deposit date: | 2009-03-11 | | Release date: | 2009-08-04 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation
Cancer Res., 69, 2009
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8I7P
 | | Crystal structure of Ricin A chain bound with N2-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycyl-L-tyrosine | | Descriptor: | 6-(2-ethyl-4-hydroxyphenyl)-1H-indazole-3-carboxamide, Ricin A chain, SULFATE ION | | Authors: | Goto, M, Sakamoto, N, Higashi, S, Kawata, R, Nagatsu, K, Saito, R. | | Deposit date: | 2023-02-01 | | Release date: | 2023-09-20 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structure of ricin toxin A chain complexed with a highly potent pterin-based small-molecular inhibitor.
J Enzyme Inhib Med Chem, 38, 2023
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9GVX
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9GVZ
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4KBK
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9GW0
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9GVY
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4KBC
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1S8G
 | | Crystal structure of Lys49-Phospholipase A2 from Agkistrodon contortrix laticinctus, fatty acid bound form | | Descriptor: | GLYCEROL, LAURIC ACID, Phospholipase A2 homolog, ... | | Authors: | Ambrosio, A.L.B, de Souza, D.H.F, Nonato, M.C, Selistre de Araujo, H.S, Ownby, C.L, Garratt, R.C. | | Deposit date: | 2004-02-02 | | Release date: | 2004-02-10 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | A Molecular Mechanism for Lys49-Phospholipase A2 Activity Based on Ligand-induced Conformational Change.
J.Biol.Chem., 280, 2005
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4MR7
 | | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist CGP54626 | | Descriptor: | (R)-(cyclohexylmethyl)[(2S)-3-{[(1S)-1-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropyl]phosphinic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid type B receptor subunit 1, ... | | Authors: | Geng, Y, Bush, M, Mosyak, L, Wang, F, Fan, Q.R. | | Deposit date: | 2013-09-17 | | Release date: | 2013-12-11 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural mechanism of ligand activation in human GABA(B) receptor.
Nature, 504, 2013
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4MR8
 | | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist CGP35348 | | Descriptor: | (S)-(3-aminopropyl)(diethoxymethyl)phosphinic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Geng, Y, Bush, M, Mosyak, L, Wang, F, Fan, Q.R. | | Deposit date: | 2013-09-17 | | Release date: | 2013-12-11 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural mechanism of ligand activation in human GABA(B) receptor.
Nature, 504, 2013
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4MS3
 | | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the endogenous agonist GABA | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid type B receptor subunit 1, ... | | Authors: | Geng, Y, Bush, M, Mosyak, L, Wang, F, Fan, Q.R. | | Deposit date: | 2013-09-18 | | Release date: | 2013-12-11 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural mechanism of ligand activation in human GABA(B) receptor.
Nature, 504, 2013
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5CA0
 | | Crystal structure of T2R-TTL-Lexibulin complex | | Descriptor: | 1-ethyl-3-[2-methoxy-4-(5-methyl-4-{[(1S)-1-(pyridin-3-yl)butyl]amino}pyrimidin-2-yl)phenyl]urea, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | Authors: | Wang, Y, Yu, Y, Chen, Q, Yang, J. | | Deposit date: | 2015-06-29 | | Release date: | 2015-11-04 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.501 Å) | | Cite: | Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery.
Febs J., 283, 2016
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1XF7
 | | High Resolution NMR Structure of the Wilms' Tumor Suppressor Protein (WT1) Finger 3 | | Descriptor: | Wilms' Tumor Protein, ZINC ION | | Authors: | Lachenmann, M.J, Ladbury, J.E, Dong, J, Huang, K, Carey, P, Weiss, M.A. | | Deposit date: | 2004-09-14 | | Release date: | 2004-12-14 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Why zinc fingers prefer zinc: ligand-field symmetry and the hidden thermodynamics of metal ion selectivity
Biochemistry, 43, 2004
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2Z0W
 | | Crystal structure of the 2nd CAP-Gly domain in human Restin-like protein 2 reveals a swapped-dimer | | Descriptor: | CAP-Gly domain-containing linker protein 4 | | Authors: | Saito, K, Yoshikawa, S, Nishino, A, Murayama, K, Terada, T, Shirouzu, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-05-07 | | Release date: | 2007-11-13 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of the 2nd CAP-Gly domain in human Restin-like protein 2 reveals a swapped-dimer
To be Published
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2Z13
 | | Crystal structure of the N-terminal DUF1126 in human EF-hand domain | | Descriptor: | EF-hand domain-containing family member C2 | | Authors: | Saito, K, Kishishita, S, Nishino, A, Murayama, K, Terada, T, Shirouzu, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-05-07 | | Release date: | 2007-11-13 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Crystal structure of the N-terminal DUF1126 in human EF-hand domain
To be Published
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2Z15
 | | Crystal structure of human Tob1 protein | | Descriptor: | Protein Tob1 | | Authors: | Saito, K, Kishishita, S, Nishino, A, Murayama, K, Terada, T, Shirouzu, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-05-08 | | Release date: | 2007-11-13 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of human Tob1 protein
To be Published
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3OF6
 | | Human pre-T cell receptor crystal structure | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Pre T-cell antigen receptor alpha, T cell receptor beta chain | | Authors: | Pang, S.S. | | Deposit date: | 2010-08-13 | | Release date: | 2010-10-20 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The structural basis for autonomous dimerization of the pre-T-cell antigen receptor
Nature, 467, 2010
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2MPR
 | | MALTOPORIN FROM SALMONELLA TYPHIMURIUM | | Descriptor: | CALCIUM ION, MALTOPORIN, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose | | Authors: | Meyer, J.E.W, Schulz, G.E. | | Deposit date: | 1997-02-07 | | Release date: | 1997-04-01 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of maltoporin from Salmonella typhimurium ligated with a nitrophenyl-maltotrioside.
J.Mol.Biol., 266, 1997
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2Z14
 | | Crystal structure of the N-terminal DUF1126 in human ef-hand domain containing 2 protein | | Descriptor: | EF-hand domain-containing family member C2 | | Authors: | Saito, K, Olsen, S, Kishishita, S, Nishino, A, Murayama, K, Terada, T, Shirouzu, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-05-08 | | Release date: | 2007-11-13 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Crystal structure of the N-terminal DUF1126 in human ef-hand domain containing 2 protein
To be Published
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1YI4
 | | Structure of Pim-1 bound to adenosine | | Descriptor: | ADENOSINE, Proto-oncogene serine/threonine-protein kinase Pim-1 | | Authors: | Jacobs, M.D, Black, J, Futer, O, Swenson, L, Hare, B, Fleming, M, Saxena, K. | | Deposit date: | 2005-01-11 | | Release date: | 2005-01-25 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.
J.Biol.Chem., 280, 2005
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3NYU
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1S8H
 | | Crystal structure of Lys49-Phospholipase A2 from Agkistrodon contortrix laticinctus, first fatty acid free form | | Descriptor: | Phospholipase A2 homolog, SULFATE ION | | Authors: | Ambrosio, A.L.B, de Souza, D.H.F, Nonato, M.C, Selistre de Araujo, H.S, Ownby, C.L, Garratt, R.C. | | Deposit date: | 2004-02-02 | | Release date: | 2004-02-10 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | A Molecular Mechanism for Lys49-Phospholipase A2 Activity Based on Ligand-induced Conformational Change.
J.Biol.Chem., 280, 2005
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4D4N
 | | Nitrosyl complex of the D121A variant of cytochrome c prime from Alcaligenes xylosoxidans | | Descriptor: | CYTOCHROME C', HEME C, NITRIC OXIDE | | Authors: | Gahfoor, D.D, Kekilli, D, Abdullah, G.H, Dworkowski, F.S.N, Hassan, H.G, Wilson, M.T, Hough, M.A, Strange, R.W. | | Deposit date: | 2014-10-30 | | Release date: | 2015-09-09 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Hydrogen Bonding of the Dissociated Histidine Ligand is not Required for Formation of a Proximal No Adduct in Cytochrome C'.
J.Biol.Inorg.Chem., 20, 2015
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1EJI
 | | RECOMBINANT SERINE HYDROXYMETHYLTRANSFERASE (MOUSE) | | Descriptor: | 5-HYDROXYMETHYLENE-6-HYDROFOLIC ACID, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], SERINE HYDROXYMETHYLTRANSFERASE | | Authors: | Szebenyi, D.M.E, Liu, X, Kriksunov, I.A, Stover, P.J, Thiel, D.J. | | Deposit date: | 2000-03-02 | | Release date: | 2000-11-03 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure of a murine cytoplasmic serine hydroxymethyltransferase quinonoid ternary complex: evidence for asymmetric obligate dimers.
Biochemistry, 39, 2000
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