4KBK
CK1d in complex with (3S)-3-{4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]pyridin-2-yl}morpholine inhibitor
Summary for 4KBK
Entry DOI | 10.2210/pdb4kbk/pdb |
Related | 4KB8 4KBA 4KBC 4KBH |
Descriptor | Casein kinase I isoform delta, (3S)-3-{4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]pyridin-2-yl}morpholine, SULFATE ION, ... (4 entities in total) |
Functional Keywords | ser/thr kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P48730 |
Total number of polymer chains | 4 |
Total formula weight | 156751.23 |
Authors | |
Primary citation | Mente, S.,Arnold, E.,Butler, T.,Chakrapani, S.,Chandrasekaran, R.,Cherry, K.,Dirico, K.,Doran, A.,Fisher, K.,Galatsis, P.,Green, M.,Hayward, M.,Humphrey, J.,Knafels, J.,Li, J.,Liu, S.,Marconi, M.,McDonald, S.,Ohren, J.,Paradis, V.,Sneed, B.,Walton, K.,Wager, T. Ligand-protein interactions of selective casein kinase 1 delta inhibitors. J.Med.Chem., 56:6819-6828, 2013 Cited by PubMed: 23919824DOI: 10.1021/jm4006324 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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