4MS3

Crystal structure of the extracellular domain of human GABA(B) receptor bound to the endogenous agonist GABA

Summary for 4MS3

Entry DOI	10.2210/pdb4ms3/pdb
Related	4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS4
Descriptor	Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2, GAMMA-AMINO-BUTANOIC ACID, ... (5 entities in total)
Functional Keywords	heterodimeric protein complex, venus flytrap module, neurotransmitter receptor, signaling protein-agonist complex, signaling protein/agonist
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	97097.47
Authors	Geng, Y.,Bush, M.,Mosyak, L.,Wang, F.,Fan, Q.R. (deposition date: 2013-09-18, release date: 2013-12-11, Last modification date: 2023-11-15)
Primary citation	Geng, Y.,Bush, M.,Mosyak, L.,Wang, F.,Fan, Q.R. Structural mechanism of ligand activation in human GABA(B) receptor. Nature, 504:254-259, 2013 Cited by PubMed: 24305054 DOI: 10.1038/nature12725 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation