3GKW
Crystal structure of the Fab fragment of Nimotuzumab. An anti-epidermal growth factor receptor antibody
Summary for 3GKW
Entry DOI | 10.2210/pdb3gkw/pdb |
Descriptor | Heavy chain of the antibody Nimotuzumab, Light chain of the antibody Nimotuzumab, DI(HYDROXYETHYL)ETHER, ... (5 entities in total) |
Functional Keywords | immunoglobulin fold, displaced strictly conserved trp 103 following kabat numbering, immune system, antitumor protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 48244.47 |
Authors | Talavera, A.,Friemann, R.,Martinez-Fleites, C.,Moreno, E.,Krengel, U. (deposition date: 2009-03-11, release date: 2009-08-04, Last modification date: 2023-11-01) |
Primary citation | Talavera, A.,Friemann, R.,Gomez-Puerta, S.,Martinez-Fleites, C.,Garrido, G.,Rabasa, A.,Lopez-Requena, A.,Pupo, A.,Johansen, R.F.,Sanchez, O.,Krengel, U.,Moreno, E. Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation Cancer Res., 69:5851-5859, 2009 Cited by PubMed: 19584289DOI: 10.1158/0008-5472.CAN-08-4518 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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