3GKW

Crystal structure of the Fab fragment of Nimotuzumab. An anti-epidermal growth factor receptor antibody

Summary for 3GKW

Entry DOI	10.2210/pdb3gkw/pdb
Descriptor	Heavy chain of the antibody Nimotuzumab, Light chain of the antibody Nimotuzumab, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
Functional Keywords	immunoglobulin fold, displaced strictly conserved trp 103 following kabat numbering, immune system, antitumor protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	48244.47
Authors	Talavera, A.,Friemann, R.,Martinez-Fleites, C.,Moreno, E.,Krengel, U. (deposition date: 2009-03-11, release date: 2009-08-04, Last modification date: 2023-11-01)
Primary citation	Talavera, A.,Friemann, R.,Gomez-Puerta, S.,Martinez-Fleites, C.,Garrido, G.,Rabasa, A.,Lopez-Requena, A.,Pupo, A.,Johansen, R.F.,Sanchez, O.,Krengel, U.,Moreno, E. Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation Cancer Res., 69:5851-5859, 2009 Cited by PubMed: 19584289 DOI: 10.1158/0008-5472.CAN-08-4518 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation